Timothy Lezon
Timothy Lezon
Assistant Professor of Computational and Systems Biology, University of Pittsburgh
Verified email at - Homepage
Cited by
Cited by
Global dynamics of proteins: bridging between structure and function
I Bahar, TR Lezon, LW Yang, E Eyal
Annual review of biophysics 39, 23-42, 2010
Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins
I Bahar, TR Lezon, A Bakan, IH Shrivastava
Chemical reviews 110 (3), 1463-1497, 2010
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release
Y Suofu, W Li, FG Jean-Alphonse, J Jia, NK Khattar, J Li, SV Baranov, ...
Proceedings of the National Academy of Sciences 114 (38), E7997-E8006, 2017
Using the principle of entropy maximization to infer genetic interaction networks from gene expression patterns
TR Lezon, JR Banavar, M Cieplak, A Maritan, NV Fedoroff
Proceedings of the National Academy of Sciences 103 (50), 19033-19038, 2006
Evol and ProDy for bridging protein sequence evolution and structural dynamics
A Bakan, A Dutta, W Mao, Y Liu, C Chennubhotla, TR Lezon, I Bahar
Bioinformatics 30 (18), 2681-2683, 2014
Biologically relevant heterogeneity: metrics and practical insights
A Gough, AM Stern, J Maier, T Lezon, TY Shun, C Chennubhotla, ...
Slas Discovery: Advancing Life Sciences R&D 22 (3), 213-237, 2017
Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery
AH Gough, N Chen, TY Shun, TR Lezon, RC Boltz, CE Reese, J Wagner, ...
PloS one 9 (7), e102678, 2014
Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh
TR Lezon, I Bahar
Biophysical journal 102 (6), 1331-1340, 2012
Using entropy maximization to understand the determinants of structural dynamics beyond native contact topology
TR Lezon, I Bahar
PLoS computational biology 6 (6), e1000816, 2010
Global motions of the nuclear pore complex: insights from elastic network models
TR Lezon, A Sali, I Bahar
PLoS computational biology 5 (9), e1000496, 2009
Proteomic screening and lasso regression reveal differential signaling in insulin and insulin-like growth factor I (IGF1) pathways
C Erdem, AM Nagle, AJ Casa, BC Litzenburger, Y Wang, DL Taylor, ...
Molecular & Cellular Proteomics 15 (9), 3045-3057, 2016
Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers
DM Spagnolo, R Gyanchandani, Y Al-Kofahi, AM Stern, TR Lezon, ...
Journal of pathology informatics 7 (1), 47, 2016
Platform for quantitative evaluation of spatial intratumoral heterogeneity in multiplexed fluorescence images
DM Spagnolo, Y Al-Kofahi, P Zhu, TR Lezon, A Gough, AM Stern, AV Lee, ...
Cancer research 77 (21), e71-e74, 2017
Elastic network models for biomolecular dynamics: theory and application to membrane proteins and viruses
TR Lezon, IH Shrivastava, Z Yang, I Bahar
Handbook on biological networks, 129-58, 2009
The origami of life
TR Lezon, JR Banavar, A Maritan
Journal of Physics: Condensed Matter 18 (3), 847, 2006
High-content analysis with cellular and tissue systems biology: a bridge between cancer cell biology and tissue-based diagnostics
A Gough, T Lezon, JR Faeder, C Chennubhotla, RF Murphy, ...
The molecular basis of cancer, 369-392. e7, 2015
Connecting neuronal cell protective pathways and drug combinations in a Huntington’s disease model through the application of quantitative systems pharmacology
F Pei, H Li, MJ Henderson, SA Titus, A Jadhav, A Simeonov, ...
Scientific Reports 7 (1), 17803, 2017
Harnessing human microphysiology systems as key experimental models for quantitative systems pharmacology
DL Taylor, A Gough, ME Schurdak, L Vernetti, CS Chennubhotla, ...
Concepts and Principles of Pharmacology: 100 Years of the Handbook of …, 2019
Geometry of proteins: hydrogen bonding, sterics, and marginally compact tubes
JR Banavar, M Cieplak, A Flammini, TX Hoang, RD Kamien, T Lezon, ...
Physical Review E 73 (3), 031921, 2006
What determines the spectrum of protein native state structures?
TR Lezon, JR Banavar, AM Lesk, A Maritan
Proteins: Structure, Function, and Bioinformatics 63 (2), 273-277, 2006
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