| The methylation effect in medicinal chemistry EJ Barreiro, AE Kümmerle, CAM Fraga Chemical reviews 111 (9), 5215-5246, 2011 | 881 | 2011 |
| Coumarin compounds in medicinal chemistry: some important examples from the last years TM Pereira, DP Franco, F Vitorio, AE Kummerle Current topics in medicinal chemistry 18 (2), 124-148, 2018 | 195 | 2018 |
| Multicomponent reactions for the synthesis of bioactive compounds: A review CS Graebin, FV Ribeiro, KR Rogério, AE Kümmerle Current Organic Synthesis 16 (6), 855-899, 2019 | 178 | 2019 |
| Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues AG Silva, G Zapata-Sudo, AE Kummerle, CAM Fraga, EJ Barreiro, ... Bioorganic & medicinal chemistry 13 (10), 3431-3437, 2005 | 143 | 2005 |
| Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally … AE Kümmerle, M Schmitt, SVS Cardozo, C Lugnier, P Villa, AB Lopes, ... Journal of medicinal chemistry 55 (17), 7525-7545, 2012 | 128 | 2012 |
| Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives AB Lopes, E Miguez, AE Kümmerle, VM Rumjanek, CAM Fraga, ... Molecules 18 (10), 11683-11704, 2013 | 119 | 2013 |
| Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives AE Kümmerle, JM Raimundo, CM Leal, GS da Silva, TL Balliano, ... European Journal of Medicinal Chemistry 44 (10), 4004-4009, 2009 | 106 | 2009 |
| Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH) AE Kümmerle, MM Vieira, M Schmitt, ALP Miranda, CAM Fraga, ... Bioorganic & medicinal chemistry letters 19 (17), 4963-4966, 2009 | 61 | 2009 |
| Synthesis and mechanism of novel fluorescent coumarin–dihydropyrimidinone dyads obtained by the Biginelli multicomponent reaction F Vitório, TM Pereira, RN Castro, GP Guedes, CS Graebin, AE Kümmerle New Journal of Chemistry 39 (3), 2323-2332, 2015 | 57 | 2015 |
| Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline‐induced pulmonary hypertension in rats AKN Alencar, SL Pereira, TL Montagnoli, RC Maia, AE Kümmerle, ... British journal of pharmacology 169 (5), 953-962, 2013 | 54 | 2013 |
| Antihypertensive profile of 2-thienyl-3, 4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor CM Leal, SL Pereira, AE Kümmerle, DM Leal, R Tesch, ... European journal of medicinal chemistry 55, 49-57, 2012 | 52 | 2012 |
| Microwave-assisted synthesis and photophysical studies of novel fluorescent N-acylhydrazone and semicarbazone-7-OH-coumarin dyes TM Pereira, F Vitório, RC Amaral, KPS Zanoni, NYM Iha, AE Kümmerle New Journal of Chemistry 40 (10), 8846-8854, 2016 | 46 | 2016 |
| LASSBio-294, A Compound With Inotropic and Lusitropic Activity, Decreases Cardiac Remodeling and Improves Ca2+ Influx Into Sarcoplasmic Reticulum After … DG Costa, JS Da Silva, AE Kümmerle, RT Sudo, SS Landgraf, ... American journal of hypertension 23 (11), 1220-1227, 2010 | 35 | 2010 |
| Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition FCF Brito, AE Kummerle, C Lugnier, CAM Fraga, EJ Barreiro, ... European journal of pharmacology 638 (1-3), 5-12, 2010 | 31 | 2010 |
| Reações multicomponentes: Um breve histórico ea versatilidade destas reações na síntese de moléculas bioativas K Rogerio, F Vitório, A Kümmerle, C Graebin Rev. Virtual Quim 8 (6), 1934-1962, 2016 | 30 | 2016 |
| The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure NF Nadur, LL de Azevedo, L Caruso, CS Graebin, RB Lacerda, ... European journal of medicinal chemistry 212, 113123, 2021 | 28 | 2021 |
| MAOS and medicinal chemistry: Some important examples from the last years NM Nascimento-Júnior, AE Kümmerle, EJ Barreiro, CAM Fraga Molecules 16 (11), 9274-9297, 2011 | 28 | 2011 |
| Recent progress in methylation of (hetero) arenes by cross-coupling or C–H activation L Hu, YA Liu, X Liao Synlett 29 (04), 375-382, 2018 | 27 | 2018 |
| A importância das cumarinas para a química medicinal e o desenvolvimento de compostos bioativos nos últimos anos DP Franco, TM Pereira, F Vitorio, NF Nadur, RB Lacerda, AE Kümmerle Química Nova 44, 180-197, 2021 | 26 | 2021 |
| New Ru (II)–DMSO complexes containing coumarin-N-acylhydrazone hybrids: Synthesis, X-ray structures, cytotoxicity and antimicrobial activities PSVB de Almeida, TM Pereira, AE Kummerle, GP Guedes, H Silva, ... Polyhedron 171, 20-31, 2019 | 26 | 2019 |
