Aparna Gorthi
Aparna Gorthi
Postdoctoral fellow, University of Texas Health Science Center at San Antonio
Verified email at
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EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
A Gorthi, JC Romero, E Loranc, L Cao, LA Lawrence, E Goodale, ...
Nature 555 (7696), 387-391, 2018
Predicting drug response of tumors from integrated genomic profiles by deep neural networks
YC Chiu, HIH Chen, T Zhang, S Zhang, A Gorthi, LJ Wang, Y Huang, ...
BMC medical genomics 12 (1), 143-155, 2019
Nucleolar RNA polymerase II drives ribosome biogenesis
KJ Abraham, N Khosraviani, JNY Chan, A Gorthi, A Samman, DY Zhao, ...
Nature 585 (7824), 298-302, 2020
The molecular landscape of ETMR at diagnosis and relapse
S Lambo, SN Gröbner, T Rausch, SM Waszak, C Schmidt, A Gorthi, ...
Nature 576 (7786), 274-280, 2019
Alkylating agent–induced NRF2 blocks endoplasmic reticulum stress–mediated apoptosis via control of glutathione pools and protein thiol homeostasis
A Zanotto-Filho, VP Masamsetti, E Loranc, SS Tonapi, A Gorthi, X Bernard, ...
Molecular cancer therapeutics 15 (12), 3000-3014, 2016
Deep learning of pharmacogenomics resources: moving towards precision oncology
YC Chiu, HIH Chen, A Gorthi, M Mostavi, S Zheng, Y Huang, Y Chen
Briefings in bioinformatics 21 (6), 2066-2083, 2020
Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates
P Countryman, Y Fan, A Gorthi, H Pan, J Strickland, P Kaur, X Wang, J Lin, ...
Journal of Biological Chemistry 293 (3), 1054-1069, 2018
Inhibition of FoxM1-mediated DNA repair by imipramine blue suppresses breast cancer growth and metastasis
S Rajamanickam, S Panneerdoss, A Gorthi, S Timilsina, B Onyeagucha, ...
Clinical Cancer Research 22 (14), 3524-3536, 2016
Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA
H Pan, M Jin, A Ghadiyaram, P Kaur, HE Miller, HM Ta, M Liu, Y Fan, ...
Nucleic acids research 48 (10), 5639-5655, 2020
Musashi1 impacts radio-resistance in glioblastoma by controlling DNA-protein kinase catalytic subunit
PR de Araujo, A Gorthi, AE da Silva, SS Tonapi, DT Vo, SC Burns, M Qiao, ...
The American journal of pathology 186 (9), 2271-2278, 2016
Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells
A Zanotto-Filho, S Rajamanickam, E Loranc, VP Masamsetti, A Gorthi, ...
Cancer letters 425, 101-115, 2018
Reconstruction of Ewing sarcoma developmental context from mass-scale transcriptomics reveals characteristics of EWSR1-FLI1 permissibility
HE Miller, A Gorthi, N Bassani, LA Lawrence, BS Iskra, AJR Bishop
Cancers 12 (4), 948, 2020
ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair
AD Brown, BW Sager, A Gorthi, SS Tonapi, EJ Brown, AJR Bishop
PloS one 9 (3), e91222, 2014
Automated risk assessment tool for pregnancy care
A Gorthi, C Firtion, J Vepa
2009 Annual International Conference of the IEEE Engineering in Medicine and …, 2009
Ewing sarcoma fusion oncogene: at the crossroads of transcription and DNA damage response
A Gorthi, AJR Bishop
Molecular & Cellular Oncology 5 (4), e1465014, 2018
Scaffold architecture and matrix strain modulate mesenchymal cell and microvascular growth and development in a time dependent manner
G Chiou, E Jui, AC Rhea, A Gorthi, S Miar, FM Acosta, C Perez, Y Suhail, ...
Cellular and molecular bioengineering 13, 507-526, 2020
The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells
SW Criscione, MJ Martin, DB Oien, A Gorthi, RJ Miragaia, J Zhang, ...
NPJ Precision Oncology 6 (1), 95, 2022
Methods for the analysis of breast cancer disorders
N Dimitrova, S Khandige, S Kapaettu, A Gorthi, SP Kabekkodu, ...
US Patent App. 13/641,282, 2013
Cohesin SA2 and EWSR1 in R-Loop Regulation
H Wang, A Ghadiyaram, H Pan, Y Fan, P Kaur, A Gorthi, R Riehn, ...
Biophysical Journal 116 (3), 505a, 2019
Computational tools for genome-wide R-loops identification and characterisation
R Liu, A Gorthi, Y Jin, AJR Bishop, Y Chen
International Journal of Computational Biology and Drug Design 10 (2), 123-136, 2017
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