| Tracking cancer drugs in living cells by thermal profiling of the proteome MM Savitski, FBM Reinhard, H Franken, T Werner, MF Savitski, ... Science 346 (6205), 2014 | 904 | 2014 |
| A novel ϵ-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing A Weidemann, S Eggert, FBM Reinhard, M Vogel, K Paliga, G Baier, ... Biochemistry 41 (8), 2825-2835, 2002 | 500 | 2002 |
| Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry H Franken, T Mathieson, D Childs, GMA Sweetman, T Werner, I Tögel, ... Nature protocols 10 (10), 1567-1593, 2015 | 495 | 2015 |
| Thermal proteome profiling monitors ligand interactions with cellular membrane proteins FBM Reinhard, D Eberhard, T Werner, H Franken, D Childs, C Doce, ... Nature methods 12 (12), 1129-1131, 2015 | 259 | 2015 |
| Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases A Weidemann, K Paliga, U Durrwang, FBM Reinhard, O Schuckert, G Evin, ... Journal of Biological Chemistry 274 (9), 5823-5829, 1999 | 223 | 1999 |
| A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation G Bergamini, K Bell, S Shimamura, T Werner, A Cansfield, K Müller, ... Nature chemical biology 8 (6), 576-582, 2012 | 145 | 2012 |
| Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells HC Eberl, T Werner, FB Reinhard, S Lehmann, D Thomson, P Chen, ... Scientific reports 9 (1), 14159, 2019 | 51 | 2019 |
| Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease G Evin, RA Sharples, A Weidemann, FBM Reinhard, V Carbone, ... Biochemistry 40 (28), 8359-8368, 2001 | 51 | 2001 |
| Mixed Lithium Magnesium Aryl Oxides Derived from Cresol: Crystal Structures and Solution NMR Studies of an Unexpected, Magnesium-Rich Oxo Product with a Trigonal Bipyramidal … KW Henderson, RE Mulvey, FBM Reinhard, W Clegg, L Horsburgh Journal of the American Chemical Society 116 (23), 10777-10778, 1994 | 30 | 1994 |
| Optimization of orally bioavailable PI3Kδ inhibitors and identification of Vps34 as a key selectivity target ZA Henley, A Amour, N Barton, M Bantscheff, G Bergamini, SM Bertrand, ... Journal of Medicinal Chemistry 63 (2), 638-655, 2019 | 19 | 2019 |
| Clinically relevant OATP2B1 inhibitors in marketed drug space MS Unger, J Mudunuru, M Schwab, C Hopf, G Drewes, AT Nies, ... Molecular pharmaceutics 17 (2), 488-498, 2019 | 18 | 2019 |
| Screening pools of compounds against multiple endogenously expressed targets in a chemoproteomics binding assay E Salzer, E Nixon, G Drewes, F Reinhard, G Bergamini, C Rau Journal of Laboratory Automation 21 (1), 133-142, 2016 | 14 | 2016 |
| Direct automated MALDI mass spectrometry analysis of cellular transporter function: inhibition of OATP2B1 uptake by 294 drugs MS Unger, L Schumacher, T Enzlein, D Weigt, MJ Zamek-Gliszczynski, ... Analytical chemistry 92 (17), 11851-11859, 2020 | 9 | 2020 |
| Investigation of Janus kinase (JAK) inhibitors for lung delivery and the importance of aldehyde oxidase metabolism CR Wellaway, IR Baldwin, P Bamborough, D Barker, MA Bartholomew, ... Journal of Medicinal Chemistry 65 (1), 633-664, 2021 | 5 | 2021 |
| Working with small molecules: Preparing and storing stock solutions and determination of kinetic solubility A Wolf, S Shimamura, FBM Reinhard Chemical Proteomics: Methods and Protocols, 265-271, 2012 | 2 | 2012 |
| Interaction of the Presenilins with the Amyloid Precursor Protein (APP) A Weidemann, K Paliga, U Dürrwang, F Reinhard, D Zhang, R Sandbrink, ... Alzheimer's Disease: Methods and Protocols, 333-344, 2000 | 1 | 2000 |
| CELL BIOLOGY AND METABOLISM-Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases A Weidemann, K Paliga, U Durrwang, FBM Reinhard, O Schuckert, G Evin, ... Journal of Biological Chemistry 274 (9), 5823-5829, 1999 | 1 | 1999 |
| PHENYLSULFONAMIDE DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE BAUMANN-KARLHEINZ, GM JEAN, GRIEBENOW-NILS, ... WO2004080952A1, 2004 | | 2004 |
| Struktur und Funktion der Preseniline sowie ihre Wechselwirkungen mit anderen für die Alzheimer-Krankheit relevanten Proteinen F Reinhard na, 2001 | | 2001 |
| Proteolytic processing of the APP gene family members APLP-1 and APLP-2 S Eggert, FBM Reinhard, K Paliga, J Stumm, S Scheuermann, ... Neurobiology of Aging, 263, 2000 | | 2000 |
Gerard DrewesCellzome/GlaxoSmithKline R&DVerified email at gsk.com
