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Shengdar Q. Tsai
Shengdar Q. Tsai
Verified email at stjude.org - Homepage
Title
Cited by
Cited by
Year
Efficient genome editing in zebrafish using a CRISPR-Cas system
WY Hwang, Y Fu, D Reyon, ML Maeder, SQ Tsai, JD Sander, ...
Nature biotechnology 31 (3), 227-229, 2013
36882013
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
BP Kleinstiver, V Pattanayak, MS Prew, SQ Tsai, NT Nguyen, Z Zheng, ...
Nature 529 (7587), 490-495, 2016
27772016
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
SQ Tsai, Z Zheng, NT Nguyen, M Liebers, VV Topkar, V Thapar, ...
Nature biotechnology 33 (2), 187-197, 2015
22282015
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
BP Kleinstiver, MS Prew, SQ Tsai, VV Topkar, NT Nguyen, Z Zheng, ...
Nature 523 (7561), 481-485, 2015
18332015
FLASH assembly of TALENs for high-throughput genome editing
D Reyon, SQ Tsai, C Khayter, JA Foden, JD Sander, JK Joung
Nature biotechnology 30 (5), 460-465, 2012
14942012
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
SQ Tsai, N Wyvekens, C Khayter, JA Foden, V Thapar, D Reyon, ...
Nature biotechnology 32 (6), 569-576, 2014
12542014
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
SQ Tsai, NT Nguyen, J Malagon-Lopez, VV Topkar, MJ Aryee, JK Joung
Nature methods 14 (6), 607-614, 2017
7102017
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
BP Kleinstiver, MS Prew, SQ Tsai, NT Nguyen, VV Topkar, Z Zheng, ...
Nature biotechnology 33 (12), 1293-1298, 2015
6962015
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
BP Kleinstiver, SQ Tsai, MS Prew, NT Nguyen, MM Welch, JM Lopez, ...
Nature biotechnology 34 (8), 869-874, 2016
6902016
Toddler: an embryonic signal that promotes cell movement via Apelin receptors
A Pauli, ML Norris, E Valen, GL Chew, JA Gagnon, S Zimmerman, ...
Science 343 (6172), 1248636, 2014
6182014
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
ML Maeder, JF Angstman, ME Richardson, SJ Linder, VM Cascio, ...
Nature biotechnology 31 (12), 1137-1142, 2013
5862013
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
J Liao, R Karnik, H Gu, MJ Ziller, K Clement, AM Tsankov, V Akopian, ...
Nature genetics 47 (5), 469-478, 2015
5272015
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
SQ Tsai, JK Joung
Nature Reviews Genetics 17 (5), 300-312, 2016
5012016
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ...
Nature medicine 25 (5), 776-783, 2019
4262019
Genetic inactivation of CD33 in hematopoietic stem cells to enable CAR T cell immunotherapy for acute myeloid leukemia
MY Kim, KR Yu, SS Kenderian, M Ruella, S Chen, TH Shin, AA Aljanahi, ...
Cell 173 (6), 1439-1453. e19, 2018
3922018
In vivo CRISPR editing with no detectable genome-wide off-target mutations
P Akcakaya, ML Bobbin, JA Guo, J Malagon-Lopez, K Clement, SP Garcia, ...
Nature 561 (7723), 416-419, 2018
3302018
Highly efficient generation of heritable zebrafish gene mutations using homo-and heterodimeric TALENs
L Cade, D Reyon, WY Hwang, SQ Tsai, S Patel, C Khayter, JK Joung, ...
Nucleic acids research 40 (16), 8001-8010, 2012
3132012
High levels of AAV vector integration into CRISPR-induced DNA breaks
KS Hanlon, BP Kleinstiver, SP Garcia, MP Zaborowski, A Volak, SE Spirig, ...
Nature communications 10 (1), 4439, 2019
3012019
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
JP Guilinger, V Pattanayak, D Reyon, SQ Tsai, JD Sander, JK Joung, ...
Nature methods 11 (4), 429-435, 2014
2822014
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
GA Newby, JS Yen, KJ Woodard, T Mayuranathan, CR Lazzarotto, Y Li, ...
Nature 595 (7866), 295-302, 2021
2222021
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