Babita Madan
Babita Madan
Duke-NUS Medical School
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Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer
KD Proffitt, B Madan, Z Ke, V Pendharkar, L Ding, MA Lee, RN Hannoush, ...
Cancer research 73 (2), 502-507, 2013
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
Z Kabiri, G Greicius, B Madan, S Biechele, Z Zhong, H Zaribafzadeh, ...
Development 141 (11), 2206-2215, 2014
Wnt addiction of genetically defined cancers reversed by PORCN inhibition
B Madan, Z Ke, N Harmston, SY Ho, AO Frois, J Alam, DA Jeyaraj, ...
Oncogene 35 (17), 2197-2207, 2016
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
S Hart, KC Goh, V Novotny-Diermayr, CY Hu, H Hentze, YC Tan, B Madan, ...
Leukemia 25 (11), 1751-1759, 2011
Isoliquiritigenin inhibits IκB kinase activity and ROS generation to block TNF-α induced expression of cell adhesion molecules on human endothelial cells
S Kumar, A Sharma, B Madan, V Singhal, B Ghosh
Biochemical pharmacology 73 (10), 1602-1612, 2007
Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia
S Hart, KC Goh, V Novotny-Diermayr, YC Tan, B Madan, C Amalini, ...
Blood cancer journal 1 (11), e44-e44, 2011
Targeting Wnts at the source—new mechanisms, new biomarkers, new drugs
B Madan, DM Virshup
Molecular cancer therapeutics 14 (5), 1087-1094, 2015
Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5
V Madan, B Madan, U Brykczynska, F Zilbermann, K Hogeveen, K Döhner, ...
Blood, The Journal of the American Society of Hematology 113 (7), 1444-1454, 2009
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds
B Madan, MP Walker, R Young, L Quick, KA Orgel, M Ryan, P Gupta, ...
Proceedings of the National Academy of Sciences 113 (21), E2945-E2954, 2016
Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy
B Madan, MJ McDonald, GE Foxa, CR Diegel, BO Williams, DM Virshup
Bone research 6 (1), 17, 2018
2′-Hydroxychalcone inhibits nuclear factor-κB and blocks tumor necrosis factor-α-and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells
B Madan, S Batra, B Ghosh
Molecular Pharmacology 58 (3), 526-534, 2000
Polarized helper T cells in tubercular pleural effusion: phenotypic identity and selective recruitment
DK Mitra, SK Sharma, AK Dinda, MS Bindra, B Madan, B Ghosh
European journal of immunology 35 (8), 2367-2375, 2005
VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer
S Hart, V Novotny-Diermayr, KC Goh, M Williams, YC Tan, LC Ong, ...
Molecular cancer therapeutics 12 (2), 151-161, 2013
Wnts and the hallmarks of cancer
Z Zhong, J Yu, DM Virshup, B Madan
Cancer and Metastasis Reviews 39 (3), 625-645, 2020
Xanthones as inhibitors of microsomal lipid peroxidation and TNF-α induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs)
B Madan, I Singh, A Kumar, AK Prasad, HG Raj, VS Parmar, B Ghosh
Bioorganic & medicinal chemistry 10 (11), 3431-3436, 2002
The Pluripotency-Associated Gene Dppa4 Is Dispensable for Embryonic Stem Cell Identity and Germ Cell Development but Essential for Embryogenesis
B Madan, V Madan, O Weber, P Tropel, C Blum, E Kieffer, S Viville, ...
Molecular and cellular biology 29 (11), 3186-3203, 2009
TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome
S Ribi, D Baumhoer, K Lee, ASM Teo, B Madan, K Zhang, WK Kohlmann, ...
Oncotarget 6 (10), 7727, 2015
PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers
Z Zhong, S Sepramaniam, XH Chew, K Wood, MA Lee, B Madan, ...
Oncogene 38 (40), 6662-6677, 2019
Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock
B Madan, B Ghosh
Shock 19 (1), 91-96, 2003
Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis
B Madan, N Harmston, G Nallan, A Montoya, P Faull, E Petretto, ...
The Journal of clinical investigation 128 (12), 5620-5633, 2019
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