| Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors KV Gurova, JE Hill, C Guo, A Prokvolit, LG Burdelya, E Samoylova, ... Proceedings of the National Academy of Sciences 102 (48), 17448-17453, 2005 | 295 | 2005 |
| New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents K Gurova Future oncology 5 (10), 1685-1704, 2009 | 273 | 2009 |
| Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT AV Gasparian, CA Burkhart, AA Purmal, L Brodsky, M Pal, M Saranadasa, ... Science translational medicine 3 (95), 95ra74-95ra74, 2011 | 254 | 2011 |
| Inflammation and p53: a tale of two stresses AV Gudkov, KV Gurova, EA Komarova Genes & cancer 2 (4), 503-516, 2011 | 209 | 2011 |
| AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival SS Bacus, DA Altomare, L Lyass, DM Chin, MP Farrell, K Gurova, ... Oncogene 21 (22), 3532-3540, 2002 | 199 | 2002 |
| Facilitates chromatin transcription complex is an “accelerator” of tumor transformation and potential marker and target of aggressive cancers H Garcia, JC Miecznikowski, A Safina, M Commane, A Ruusulehto, ... Cell reports 4 (1), 159-173, 2013 | 138 | 2013 |
| p53 pathway in renal cell carcinoma is repressed by a dominant mechanism KV Gurova, JE Hill, OV Razorenova, PM Chumakov, AV Gudkov Cancer research 64 (6), 1951-1958, 2004 | 137 | 2004 |
| 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways C Guo, AV Gasparian, Z Zhuang, DA Bosykh, AA Komar, AV Gudkov, ... Oncogene 28 (8), 1151-1161, 2009 | 131 | 2009 |
| Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma DR Carter, J Murray, BB Cheung, L Gamble, J Koach, J Tsang, S Sutton, ... Science translational medicine 7 (312), 312ra176-312ra176, 2015 | 130 | 2015 |
| Small-molecule multidrug resistance–associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma CA Burkhart, F Watt, J Murray, M Pajic, A Prokvolit, C Xue, C Flemming, ... Cancer research 69 (16), 6573-6580, 2009 | 126 | 2009 |
| Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells H Garcia, D Fleyshman, K Kolesnikova, A Safina, M Commane, ... Oncotarget 2 (10), 783, 2011 | 112 | 2011 |
| FACT is a sensor of DNA torsional stress in eukaryotic cells A Safina, P Cheney, M Pal, L Brodsky, A Ivanov, K Kirsanov, E Lesovaya, ... Nucleic acids research 45 (4), 1925-1945, 2017 | 105 | 2017 |
| Mycoplasma infection suppresses p53, activates NF-κB and cooperates with oncogenic Ras in rodent fibroblast transformation DY Logunov, DV Scheblyakov, OV Zubkova, MM Shmarov, ... Oncogene 27 (33), 4521-4531, 2008 | 101 | 2008 |
| Structure and function of the histone chaperone FACT–Resolving FACTual issues K Gurova, HW Chang, ME Valieva, P Sandlesh, VM Studitsky Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1861 (9), 892-904, 2018 | 97 | 2018 |
| Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas JV Kichina, M Zeremski, L Aris, KV Gurova, E Walker, R Franks, AY Nikitin, ... Oncogene 25 (6), 857-866, 2006 | 95 | 2006 |
| Structure and regulation of the mouse ing1 gene: Three alternative transcripts encode two PHD finger proteins that have opposite effects on p53 function M Zeremski, JE Hill, SSS Kwek, IA Grigorian, KV Gurova, IV Garkavtsev, ... Journal of Biological Chemistry 274 (45), 32172-32181, 1999 | 91 | 1999 |
| p53 determines multidrug sensitivity of childhood neuroblastoma C Xue, M Haber, C Flemming, GM Marshall, RB Lock, KL MacKenzie, ... Cancer research 67 (21), 10351-10360, 2007 | 89 | 2007 |
| Quinacrine overcomes resistance to Erlotinib by inhibiting FACT, NF-κB, and cell-cycle progression in non–small cell lung cancer JKT Dermawan, K Gurova, J Pink, A Dowlati, S De, G Narla, N Sharma, ... Molecular cancer therapeutics 13 (9), 2203-2214, 2014 | 79 | 2014 |
| Expression of prostate specific antigen (PSA) is negatively regulated by p53 KV Gurova, OW Roklin, VI Krivokrysenko, PM Chumakov, MB Cohen, ... Oncogene 21 (1), 153-157, 2002 | 74 | 2002 |
| Pharmacological targeting of the histone chaperone complex FACT preferentially eliminates glioblastoma stem cells and prolongs survival in preclinical models JKT Dermawan, M Hitomi, DJ Silver, Q Wu, P Sandlesh, AE Sloan, ... Cancer research 76 (8), 2432-2442, 2016 | 72 | 2016 |
Andrei GudkovProfessor of Roswell Park Comprehensive Cancer CenterVerified email at roswellpark.org
