| Alzheimer's disease P Scheltens, B De Strooper, M Kivipelto, H Holstege, G Chételat, ... The Lancet 397 (10284), 1577-1590, 2021 | 654 | 2021 |
| Activation of central melanocortin pathways by fenfluramine LK Heisler, MA Cowley, LH Tecott, W Fan, MJ Low, JL Smart, ... Science 297 (5581), 609-611, 2002 | 558 | 2002 |
| Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer X Liu, H Holstege, H van der Gulden, M Treur-Mulder, J Zevenhoven, ... Proceedings of the National Academy of Sciences 104 (29), 12111-12116, 2007 | 474 | 2007 |
| Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin B Evers, R Drost, E Schut, M de Bruin, E van der Burg, PWB Derksen, ... Clinical Cancer Research 14 (12), 3916-3925, 2008 | 361 | 2008 |
| BRD7 is a candidate tumour suppressor gene required for p53 function J Drost, F Mantovani, F Tocco, R Elkon, A Comel, H Holstege, ... Nature cell biology 12 (4), 380-389, 2010 | 218 | 2010 |
| New insights into the genetic etiology of Alzheimer’s disease and related dementias C Bellenguez, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, ... Nature genetics 54 (4), 412-436, 2022 | 207 | 2022 |
| High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer H Holstege, SA Joosse, CTM van Oostrom, PM Nederlof, A de Vries, ... Cancer research 69 (8), 3625-3633, 2009 | 196 | 2009 |
| Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis H Holstege, W Pfeiffer, D Sie, M Hulsman, TJ Nicholas, CC Lee, T Ross, ... Genome research 24 (5), 733-742, 2014 | 179 | 2014 |
| A meta-analysis of genome-wide association studies identifies multiple longevity genes J Deelen, DS Evans, DE Arking, N Tesi, M Nygaard, X Liu, MK Wojczynski, ... Nature communications 10 (1), 3669, 2019 | 174 | 2019 |
| WISECONDOR: detection of fetal aberrations from shallow sequencing maternal plasma based on a within-sample comparison scheme R Straver, EA Sistermans, H Holstege, A Visser, CBM Oudejans, ... Nucleic acids research 42 (5), e31-e31, 2014 | 134 | 2014 |
| Genome-wide significant risk factors for Alzheimer’s disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment A Lacour, A Espinosa, E Louwersheimer, S Heilmann, I Hernández, ... Molecular psychiatry 22 (1), 153-160, 2017 | 100 | 2017 |
| Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores I De Rojas, S Moreno-Grau, N Tesi, B Grenier-Boley, V Andrade, ... Nature communications 12 (1), 3417, 2021 | 94 | 2021 |
| Human and mouse oligonucleotide-based array CGH P van den IJssel, M Tijssen, SF Chin, P Eijk, B Carvalho, E Hopmans, ... Nucleic Acids Research 33 (22), e192-e192, 2005 | 93 | 2005 |
| A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization YJ Chung, J Jonkers, H Kitson, H Fiegler, S Humphray, C Scott, S Hunt, ... Genome research 14 (1), 188-196, 2004 | 91 | 2004 |
| Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategy H Holstege, SJ Van Der Lee, M Hulsman, TH Wong, JGJ Van Rooij, ... European Journal of Human Genetics 25 (8), 973-981, 2017 | 88 | 2017 |
| Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases R Guerreiro, V Escott-Price, L Darwent, L Parkkinen, O Ansorge, ... Neurobiology of aging 38, 214. e7-214. e10, 2016 | 88 | 2016 |
| A High-Throughput Pharmaceutical Screen Identifies Compounds with Specific Toxicity against BRCA2-Deficient TumorsA Screen for Compounds Toxic to BRCA2-Deficient Tumors B Evers, E Schut, E van der Burg, TM Braumuller, DA Egan, H Holstege, ... Clinical Cancer Research 16 (1), 99-108, 2010 | 88 | 2010 |
| A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the … SJ Van Der Lee, OJ Conway, I Jansen, MM Carrasquillo, L Kleineidam, ... Acta neuropathologica 138, 237-250, 2019 | 82 | 2019 |
| Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease A Lechel, H Holstege, Y Begus, A Schienke, K Kamino, U Lehmann, ... Gastroenterology 132 (4), 1465-1475, 2007 | 82 | 2007 |
| BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations H Holstege, HM Horlings, A Velds, A Langerřd, AL Břrresen-Dale, ... BMC cancer 10, 1-15, 2010 | 81 | 2010 |
Philip ScheltensProfessor of NeurologyVerified email at amsterdamumc.nl
