raffaele de francesco
raffaele de francesco
Istituto Nazionale Genetica Molecolare - INGM and DiSFeB, University of Milan, Italy
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Identification and properties of the RNA‐dependent RNA polymerase of hepatitis C virus.
SE Behrens, L Tomei, R De Francesco
The EMBO journal 15 (1), 12-22, 1996
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
A Vannini, C Volpari, G Filocamo, EC Casavola, M Brunetti, D Renzoni, ...
Proceedings of the National Academy of Sciences 101 (42), 15064-15069, 2004
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
S Bressanelli, L Tomei, A Roussel, I Incitti, RL Vitale, M Mathieu, ...
Proceedings of the National Academy of Sciences 96 (23), 13034-13039, 1999
Challenges and successes in developing new therapies for hepatitis C
R De Francesco, G Migliaccio
Nature 436 (7053), 953-960, 2005
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
A Lahm, C Paolini, M Pallaoro, MC Nardi, P Jones, P Neddermann, ...
Proceedings of the National Academy of Sciences 104 (44), 17335-17340, 2007
Transcriptional landscape of human tissue lymphocytes unveils uniqueness of tumor-infiltrating T regulatory cells
M De Simone, A Arrigoni, G Rossetti, P Gruarin, V Ranzani, C Politano, ...
Immunity 45 (5), 1135-1147, 2016
NS3 is a serine protease required for processing of hepatitis C virus polyprotein
L Tomei, C Failla, E Santolini, R De Francesco, N La Monica
Journal of virology 67 (7), 4017-4026, 1993
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins
C Failla, L Tomei, R De Francesco
Journal of virology 68 (6), 3753-3760, 1994
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
S Bressanelli, L Tomei, FA Rey, R De Francesco
Journal of virology 76 (7), 3482-3492, 2002
The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA
A Vannini, C Volpari, C Gargioli, E Muraglia, R Cortese, R De Francesco, ...
The EMBO journal 21 (17), 4393-4401, 2002
Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs
SS Carroll, JE Tomassini, M Bosserman, K Getty, MW Stahlhut, AB Eldrup, ...
Journal of Biological Chemistry 278 (14), 11979-11984, 2003
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses
G Nizzoli, J Krietsch, A Weick, S Steinfelder, F Facciotti, P Gruarin, ...
Blood, The Journal of the American Society of Hematology 122 (6), 932-942, 2013
Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro
G Migliaccio, JE Tomassini, SS Carroll, L Tomei, S Altamura, B Bhat, ...
Journal of Biological Chemistry 278 (49), 49164-49170, 2003
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain
MJ Bottomley, PL Surdo, P Di Giovine, A Cirillo, R Scarpelli, F Ferrigno, ...
Journal of Biological Chemistry 283 (39), 26694-26704, 2008
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
R De Francesco, L Tomei, S Altamura, V Summa, G Migliaccio
Antiviral research 58 (1), 1-16, 2003
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4
V Ranzani, G Rossetti, I Panzeri, A Arrigoni, RJP Bonnal, S Curti, ...
Nature immunology 16 (3), 318-325, 2015
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 Ċ resolution structure in a hexagonal crystal form
Y Yan, Y Li, S Munshi, V Sardana, JL Cole, M Sardana, LC Kuo, Z Chen, ...
Protein Science 7 (4), 837-847, 1998
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b
RL Rossi, G Rossetti, L Wenandy, S Curti, A Ripamonti, RJP Bonnal, ...
Nature immunology 12 (8), 796-803, 2011
Product inhibition of the hepatitis C virus NS3 protease
C Steinkühler, G Biasiol, M Brunetti, A Urbani, U Koch, R Cortese, A Pessi, ...
Biochemistry 37 (25), 8899-8905, 1998
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex
A Vannini, C Volpari, P Gallinari, P Jones, M Mattu, A Carfí, ...
EMBO reports 8 (9), 879-884, 2007
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