Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients N Lallous, SV Volik, S Awrey, E Leblanc, R Tse, J Murillo, K Singh, ... Genome Biology 17 (10), 2016 | 221 | 2016 |
Moving towards precision urologic oncology: targeting enzalutamide-resistant prostate cancer and mutated forms of the androgen receptor using the novel inhibitor darolutamide … H Borgmann, N Lallous, D Ozistanbullu, E Beraldi, N Paul, K Dalal, L Fazli, ... European urology 73 (1), 4-8, 2018 | 85 | 2018 |
Targeting alternative sites on the androgen receptor to treat castration-resistant prostate cancer N Lallous, K Dalal, A Cherkasov, PS Rennie International journal of molecular sciences 14 (6), 12496-12519, 2013 | 84 | 2013 |
Identification of a potent antiandrogen that targets the BF3 site of the androgen receptor and inhibits enzalutamide-resistant prostate cancer RSN Munuganti, MDH Hassona, E Leblanc, K Frewin, K Singh, D Ma, ... Chemistry & biology 21 (11), 1476-1485, 2014 | 81 | 2014 |
Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD A Grande-García, N Lallous, C Díaz-Tejada, S Ramón-Maiques Structure 22 (2), 185-198, 2014 | 75 | 2014 |
Androgen receptor-binding sites are highly mutated in prostate cancer T Morova, DR McNeill, N Lallous, M Gönen, K Dalal, DM Wilson III, ... Nature communications 11 (1), 832, 2020 | 54 | 2020 |
Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models L Nappi, AH Aguda, N Al Nakouzi, B Lelj-Garolla, E Beraldi, N Lallous, ... The Journal of clinical investigation 130 (2), 699-714, 2020 | 52 | 2020 |
The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers N Lallous, P Legrand, AG McEwen, S Ramón-Maiques, JP Samama, ... PloS one 6 (11), e27599, 2011 | 52 | 2011 |
Androgen receptor plasticity and its implications for prostate cancer therapy O Snow, N Lallous, K Singh, N Lack, P Rennie, A Cherkasov Cancer treatment reviews 81, 101871, 2019 | 49 | 2019 |
Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer LA Carabet, N Lallous, E Leblanc, F Ban, H Morin, S Lawn, F Ghaidi, ... European journal of medicinal chemistry 160, 108-119, 2018 | 49 | 2018 |
An oncofetal glycosaminoglycan modification provides therapeutic access to cisplatin-resistant bladder cancer R Seiler, HZ Oo, D Tortora, TM Clausen, CK Wang, G Kumar, MA Pereira, ... European urology 72 (1), 142-150, 2017 | 48 | 2017 |
Dynamic phase separation of the androgen receptor and its coactivators key to regulate gene expression F Zhang, M Biswas, S Massah, J Lee, S Lingadahalli, S Wong, C Wells, ... Nucleic Acids Research 51 (1), 99-116, 2023 | 37 | 2023 |
Bypassing drug resistance mechanisms of prostate cancer with small molecules that target androgen Receptor–Chromatin interactions K Dalal, M Che, NS Que, A Sharma, R Yang, N Lallous, H Borgmann, ... Molecular cancer therapeutics 16 (10), 2281-2291, 2017 | 37 | 2017 |
Discovery of new catalytic topoisomerase II inhibitors for anticancer therapeutics VM Matias-Barrios, M Radaeva, Y Song, Z Alperstein, AR Lee, V Schmitt, ... Frontiers in oncology 10, 633142, 2021 | 36 | 2021 |
Computer-aided discovery of small molecules targeting the RNA splicing activity of hnRNP A1 in castration-resistant prostate cancer LA Carabet, E Leblanc, N Lallous, H Morin, F Ghaidi, J Lee, PS Rennie, ... Molecules 24 (4), 763, 2019 | 32 | 2019 |
Targeting binding function-3 of the androgen receptor blocks its co-chaperone interactions, nuclear translocation, and activation N Lallous, E Leblanc, RSN Munuganti, MDH Hassona, NA Nakouzi, ... Molecular cancer therapeutics 15 (12), 2936-2945, 2016 | 30 | 2016 |
In silico discovery and validation of potent small-molecule inhibitors targeting the activation function 2 site of human oestrogen receptor α K Singh, RSN Munuganti, E Leblanc, YL Lin, E Leung, N Lallous, M Butler, ... Breast Cancer Research 17, 1-17, 2015 | 30 | 2015 |
Development of an androgen receptor inhibitor targeting the N-Terminal domain of androgen receptor for treatment of castration resistant prostate cancer F Ban, E Leblanc, AD Cavga, CCF Huang, MR Flory, F Zhang, ... Cancers 13 (14), 3488, 2021 | 22 | 2021 |
Dual-inhibitors of N-Myc and AURKA as potential therapy for neuroendocrine prostate cancer AT Ton, K Singh, H Morin, F Ban, E Leblanc, J Lee, N Lallous, ... International journal of molecular sciences 21 (21), 8277, 2020 | 20 | 2020 |
Cheminformatics Modeling of Adverse Drug Responses by Clinically Relevant Mutants of Human Androgen Receptor AC Naman Paul, Lavinia Arielle Carabet, Nada Lallous, Takeshi Yamazaki ... Journal of Chemical Information and Modeling, 2016 | 20 | 2016 |