A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, ... Nature 583 (7816), 459-468, 2020 | 4611 | 2020 |
Consensus development conference on antipsychotic drugs and obesity and diabetes American Diabetes Association,, American Psychiatric Association,, ... Diabetes care 27 (2), 596-601, 2004 | 2763 | 2004 |
The expanded biology of serotonin M Berger, JA Gray, BL Roth Annual review of medicine 60 (1), 355-366, 2009 | 2590 | 2009 |
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand BN Armbruster, X Li, MH Pausch, S Herlitze, BL Roth Proceedings of the National Academy of Sciences 104 (12), 5163-5168, 2007 | 2240 | 2007 |
Relating protein pharmacology by ligand chemistry MJ Keiser, BL Roth, BN Armbruster, P Ernsberger, JJ Irwin, BK Shoichet Nature biotechnology 25 (2), 197-206, 2007 | 2200 | 2007 |
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression G Rajkowska, JJ Miguel-Hidalgo, J Wei, G Dilley, SD Pittman, HY Meltzer, ... Biological psychiatry 45 (9), 1085-1098, 1999 | 1957 | 1999 |
Predicting new molecular targets for known drugs MJ Keiser, V Setola, JJ Irwin, C Laggner, AI Abbas, SJ Hufeisen, ... Nature 462 (7270), 175-181, 2009 | 1896 | 2009 |
DREADDs for neuroscientistss BL Roth Neuron, 2016 | 1740 | 2016 |
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice MJ Krashes, S Koda, CP Ye, SC Rogan, AC Adams, DS Cusher, ... The Journal of clinical investigation 121 (4), 1424-1428, 2011 | 1514 | 2011 |
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia BL Roth, DJ Sheffler, WK Kroeze Nature reviews Drug discovery 3 (4), 353-359, 2004 | 1392 | 2004 |
Functional selectivity and classical concepts of quantitative pharmacology JD Urban, WP Clarke, M Von Zastrow, DE Nichols, B Kobilka, H Weinstein, ... Journal of Pharmacology and Experimental Therapeutics 320 (1), 1-13, 2007 | 1327 | 2007 |
Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology DA Shapiro, S Renock, E Arrington, LA Chiodo, LX Liu, DR Sibley, ... Neuropsychopharmacology 28 (8), 1400-1411, 2003 | 1252 | 2003 |
Structure of the human κ-opioid receptor in complex with JDTic H Wu, D Wacker, M Mileni, V Katritch, GW Han, E Vardy, W Liu, ... Nature 485 (7398), 327-332, 2012 | 1093 | 2012 |
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs WK Kroeze, SJ Hufeisen, BA Popadak, SM Renock, SA Steinberg, ... Neuropsychopharmacology 28 (3), 519-526, 2003 | 1086 | 2003 |
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons MS Goldberg, SM Fleming, JJ Palacino, C Cepeda, HA Lam, A Bhatnagar, ... Journal of Biological Chemistry 278 (44), 43628-43635, 2003 | 1068 | 2003 |
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors GM Alexander, SC Rogan, AI Abbas, BN Armbruster, Y Pei, JA Allen, ... Neuron 63 (1), 27-39, 2009 | 1063 | 2009 |
Structure-based discovery of opioid analgesics with reduced side effects A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ... Nature 537 (7619), 185-190, 2016 | 994 | 2016 |
Salvinorin A: a potent naturally occurring nonnitrogenous κ opioid selective agonist BL Roth, K Baner, R Westkaemper, D Siebert, KC Rice, SA Steinberg, ... Proceedings of the National Academy of Sciences 99 (18), 11934-11939, 2002 | 964 | 2002 |
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors BL Roth, SC Craigo, MS Choudhary, A Uluer, FJ Monsma Jr, Y Shen, ... Journal of Pharmacology and Experimental Therapeutics 268 (3), 1403-1410, 1994 | 943 | 1994 |
Automated design of ligands to polypharmacological profiles J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ... Nature 492 (7428), 215-220, 2012 | 868 | 2012 |