Benjamin Ng
Benjamin Ng
National Heart Centre Singapore
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IL-11 is a crucial determinant of cardiovascular fibrosis
S Schafer, S Viswanathan, AA Widjaja, WW Lim, A Moreno-Moral, ...
Nature 552 (7683), 110-115, 2017
Titin-truncating variants affect heart function in disease cohorts and the general population
S Schafer, A De Marvao, E Adami, LR Fiedler, B Ng, E Khin, ...
Nature genetics 49 (1), 46-53, 2017
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
B Ng, J Dong, G D’Agostino, S Viswanathan, AA Widjaja, WW Lim, ...
Science translational medicine 11 (511), eaaw1237, 2019
Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of nonalcoholic steatohepatitis
AA Widjaja, BK Singh, E Adami, S Viswanathan, J Dong, GA D’Agostino, ...
Gastroenterology 157 (3), 777-792. e14, 2019
Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression
TM Liu, WM Ng, HS Tan, D Vinitha, Z Yang, JB Fan, Y Zou, JH Hui, ...
Stem cells and development 22 (2), 268-278, 2013
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
J Dong, S Viswanathan, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, ...
Nature communications 12 (1), 66, 2021
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway
B Ng, SA Cook, S Schafer
Experimental & Molecular Medicine 52 (12), 1871-1878, 2020
Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models
WW Lim, B Corden, B Ng, K Vanezis, G D’Agostino, AA Widjaja, WH Song, ...
Scientific reports 10 (1), 17853, 2020
Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease
B Ng, J Dong, S Viswanathan, AA Widjaja, BS Paleja, E Adami, NSJ Ko, ...
The FASEB Journal 34 (9), 11802-11815, 2020
Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
WW Lim, B Ng, A Widjaja, C Xie, L Su, N Ko, SY Lim, XY Kwek, S Lim, ...
PLoS One 15 (1), e0227505, 2020
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury
AA Widjaja, J Dong, E Adami, S Viswanathan, B Ng, LS Pakkiri, ...
Science Translational Medicine 13 (597), eaba8146, 2021
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts
E Adami, S Viswanathan, AA Widjaja, B Ng, S Chothani, N Zhihao, J Tan, ...
Rheumatology 60 (12), 5820-5826, 2021
Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption
EC Khor, T Abel, J Tickner, SM Chim, C Wang, T Cheng, B Ng, PY Ng, ...
PloS one 8 (8), e70815, 2013
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis
B Ng, AA Widjaja, S Viswanathan, J Dong, SP Chothani, S Lim, ...
Scientific Reports 11 (1), 14088, 2021
Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo
J Zhou, B Ng, NSJ Ko, LR Fiedler, E Khin, A Lim, NE Sahib, Y Wu, ...
Human molecular genetics 28 (12), 1971-1981, 2019
Inhibition of IL11 signaling reduces aortic pathology in murine marfan syndrome
WW Lim, J Dong, B Ng, AA Widjaja, C Xie, L Su, XY Kwek, NGZ Tee, ...
Circulation Research 130 (5), 728-740, 2022
IL11 activates pancreatic stellate cells and causes pancreatic inflammation, fibrosis and atrophy in a mouse model of pancreatitis
B Ng, S Viswanathan, AA Widjaja, WW Lim, SG Shekeran, JWT Goh, ...
International Journal of Molecular Sciences 23 (7), 3549, 2022
Treatment of SMC mediated disease
SA Cook, S Schaefer, WW Lim, BWM Ng
US Patent 11,780,898, 2023
Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments
X Yang, D Teguh, JP Wu, B He, TB Kirk, S Qin, S Li, H Chen, W Xue, B Ng, ...
Arthritis Research & Therapy 17, 1-8, 2015
Redefining Interleukin 11 as a regeneration-limiting hepatotoxin
AA Widjaja, J Dong, E Adami, S Viswanathan, B Ng, BK Singh, WW Lim, ...
bioRxiv, 830018, 2019
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