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Wei Wen Lim
Wei Wen Lim
National Heart Centre Singapore, Duke-NUS Medical School
Verified email at nhcs.com.sg
Title
Cited by
Cited by
Year
IL-11 is a crucial determinant of cardiovascular fibrosis
S Schafer, S Viswanathan, AA Widjaja, WW Lim, A Moreno-Moral, ...
Nature 552 (7683), 110-115, 2017
5262017
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
B Ng, J Dong, G D’Agostino, S Viswanathan, AA Widjaja, WW Lim, ...
Science translational medicine 11 (511), eaaw1237, 2019
2162019
Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of nonalcoholic steatohepatitis
AA Widjaja, BK Singh, E Adami, S Viswanathan, J Dong, GA D’Agostino, ...
Gastroenterology 157 (3), 777-792. e14, 2019
2112019
Bipolar electrogram shannon entropy at sites of rotational activation: implications for ablation of atrial fibrillation
AN Ganesan, P Kuklik, DH Lau, AG Brooks, M Baumert, WW Lim, ...
Circulation: Arrhythmia and Electrophysiology 6 (1), 48-57, 2013
1512013
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
J Dong, S Viswanathan, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, ...
Nature communications 12 (1), 66, 2021
852021
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury
AA Widjaja, J Dong, E Adami, S Viswanathan, B Ng, LS Pakkiri, ...
Science Translational Medicine 13 (597), eaba8146, 2021
57*2021
Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models
WW Lim, B Corden, B Ng, K Vanezis, G D’Agostino, AA Widjaja, WH Song, ...
Scientific reports 10 (1), 17853, 2020
502020
Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
WW Lim, B Ng, A Widjaja, C Xie, L Su, N Ko, SY Lim, XY Kwek, S Lim, ...
PLoS One 15 (1), e0227505, 2020
502020
A high-resolution map of human RNA translation
SP Chothani, E Adami, AA Widjaja, SR Langley, S Viswanathan, CJ Pua, ...
Molecular cell 82 (15), 2885-2899. e8, 2022
472022
IL11 stimulates IL33 expression and proinflammatory fibroblast activation across tissues
AA Widjaja, S Chothani, S Viswanathan, JWT Goh, WW Lim, SA Cook
International Journal of Molecular Sciences 23 (16), 8900, 2022
282022
Inhibition of IL11 signaling reduces aortic pathology in murine marfan syndrome
WW Lim, J Dong, B Ng, AA Widjaja, C Xie, L Su, XY Kwek, NGZ Tee, ...
Circulation Research 130 (5), 728-740, 2022
262022
IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
AA Widjaja, S Viswanathan, JGW Ting, J Tan, SG Shekeran, D Carling, ...
IScience 25 (8), 2022
202022
IL11 activates pancreatic stellate cells and causes pancreatic inflammation, fibrosis and atrophy in a mouse model of pancreatitis
B Ng, S Viswanathan, AA Widjaja, WW Lim, SG Shekeran, JWT Goh, ...
International Journal of Molecular Sciences 23 (7), 3549, 2022
192022
Therapeutic targeting of interleukin-11 signalling reduces pressure overload–induced cardiac fibrosis in mice
B Corden, WW Lim, W Song, X Chen, NSJ Ko, L Su, NGZ Tee, E Adami, ...
Journal of Cardiovascular Translational Research 14, 222-228, 2021
182021
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease
AA Widjaja, S Viswanathan, SG Shekeran, E Adami, WW Lim, S Chothani, ...
Nature Communications 13 (1), 7497, 2022
152022
Treatment of SMC mediated disease
SA Cook, S Schaefer, WW Lim, BWM Ng
US Patent 11,780,898, 2023
142023
Antibody‐mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload
WW Lim, B Corden, L Ye, S Viswanathan, AA Widjaja, C Xie, L Su, ...
Clinical and Experimental Pharmacology and Physiology 48 (4), 605-613, 2021
132021
Electrophysiological and structural remodeling of the atria in a mouse model of troponin-I mutation linked hypertrophic cardiomyopathy: implications for atrial fibrillation
WW Lim, M Neo, S Thanigaimani, P Kuklik, AN Ganesan, DH Lau, ...
International Journal of Molecular Sciences 22 (13), 6941, 2021
102021
Interleukin-11: A potential biomarker and molecular therapeutic target in non-small cell lung cancer
JH Leung, B Ng, WW Lim
Cells 11 (14), 2257, 2022
82022
Cardiomyocyte-restricted expression of IL11 causes cardiac fibrosis, inflammation, and dysfunction
M Sweeney, K O’Fee, C Villanueva-Hayes, E Rahman, M Lee, K Vanezis, ...
International Journal of Molecular Sciences 24 (16), 12989, 2023
52023
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