Gopal Sapparapu
Gopal Sapparapu
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Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
G Sapparapu, E Fernandez, N Kose, B Cao, JM Fox, RG Bombardi, ...
Nature 540 (7633), 443-447, 2016
Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection
AI Flyak, X Shen, CD Murin, HL Turner, JA David, ML Fusco, R Lampley, ...
Cell 164 (3), 392-405, 2016
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
N Kose, JM Fox, G Sapparapu, R Bombardi, RN Tennekoon, AD De Silva, ...
Science immunology 4 (35), eaaw6647, 2019
Mechanism of human antibody-mediated neutralization of Marburg virus
AI Flyak, PA Ilinykh, CD Murin, T Garron, X Shen, ML Fusco, T Hashiguchi, ...
Cell 160 (5), 893-903, 2015
A human antibody against Zika virus crosslinks the E protein to prevent infection
SS Hasan, A Miller, G Sapparapu, E Fernandez, T Klose, F Long, ...
Nature communications 8 (1), 14722, 2017
Isolation and characterization of broad and ultrapotent human monoclonal antibodies with therapeutic activity against chikungunya virus
SA Smith, LA Silva, JM Fox, AI Flyak, N Kose, G Sapparapu, ...
Cell host & microbe 18 (1), 86-95, 2015
Cross-neutralizing and protective human antibody specificities to poxvirus infections
I Gilchuk, P Gilchuk, G Sapparapu, R Lampley, V Singh, N Kose, DL Blum, ...
Cell 167 (3), 684-694. e9, 2016
Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore
MS Aiyegbo, G Sapparapu, BW Spiller, IM Eli, DR Williams, R Kim, ...
PloS one 8 (5), e61101, 2013
Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region
AI Flyak, N Kuzmina, CD Murin, C Bryan, E Davidson, P Gilchuk, ...
Nature microbiology 3 (6), 670-677, 2018
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations
NJ Thornburg, H Zhang, S Bangaru, G Sapparapu, N Kose, RM Lampley, ...
The Journal of clinical investigation 126 (4), 1482-1494, 2016
Mapping the human memory B cell and serum neutralizing antibody responses to dengue virus serotype 4 infection and vaccination
UK Nivarthi, N Kose, G Sapparapu, D Widman, E Gallichotte, JM Pfaff, ...
Journal of virology 91 (5), 10.1128/jvi. 02041-16, 2017
Dengue virus prM-specific human monoclonal antibodies with virus replication-enhancing properties recognize a single immunodominant antigenic site
SA Smith, UK Nivarthi, R de Alwis, N Kose, G Sapparapu, R Bombardi, ...
Journal of virology 90 (2), 780-789, 2016
Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity
F Long, RH Fong, SK Austin, Z Chen, T Klose, A Fokine, Y Liu, J Porta, ...
Proceedings of the National Academy of Sciences 112 (45), 13898-13903, 2015
Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody
S Shanker, R Czakó, G Sapparapu, G Alvarado, M Viskovska, B Sankaran, ...
Proceedings of the National Academy of Sciences 113 (40), E5830-E5837, 2016
Exceptional amyloid β peptide hydrolyzing activity of nonphysiological immunoglobulin variable domain scaffolds
H Taguchi, S Planque, G Sapparapu, S Boivin, M Hara, Y Nishiyama, ...
Journal of Biological Chemistry 283 (52), 36724-36733, 2008
Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and …
IP Thomsen, G Sapparapu, DBA James, JE Cassat, M Nagarsheth, ...
The Journal of infectious diseases 215 (7), 1124-1131, 2017
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses
NJ Thornburg, DP Nannemann, DL Blum, JA Belser, TM Tumpey, ...
The Journal of clinical investigation 123 (10), 4405-4409, 2013
Mouse and human monoclonal antibodies protect against infection by multiple genotypes of Japanese encephalitis virus
E Fernandez, N Kose, MA Edeling, J Adhikari, G Sapparapu, SM Lazarte, ...
MBio 9 (1), 10.1128/mbio. 00008-18, 2018
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth
JR Willis, G Sapparapu, S Murrell, JP Julien, V Singh, HG King, Y Xia, ...
The Journal of clinical investigation 125 (6), 2523-2531, 2015
Frequent use of the IgA isotype in human B cells encoding potent norovirus-specific monoclonal antibodies that block HBGA binding
G Sapparapu, R Czako, G Alvarado, S Shanker, BVV Prasad, RL Atmar, ...
PLoS Pathogens 12 (6), e1005719, 2016
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