Christiaan Klijn
Christiaan Klijn
Senior Director of Discovery Data Science, Genmab
Verified email at
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A comprehensive transcriptional portrait of human cancer cell lines
C Klijn, S Durinck, EW Stawiski, PM Haverty, Z Jiang, H Liu, J Degenhardt, ...
Nature biotechnology 33 (3), 306-312, 2015
Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer ImmunotherapyCharacterization of TGFβ-activated …
CX Dominguez, S Müller, S Keerthivasan, H Koeppen, J Hung, S Gierke, ...
Cancer discovery 10 (2), 232-253, 2020
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
R Drost, P Bouwman, S Rottenberg, U Boon, E Schut, S Klarenbeek, ...
Cancer cell 20 (6), 797-809, 2011
USP7 small-molecule inhibitors interfere with ubiquitin binding
L Kategaya, P Di Lello, L Rougé, R Pastor, KR Clark, J Drummond, ...
Nature 550 (7677), 534-538, 2017
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events
J Liu, W Lee, Z Jiang, Z Chen, S Jhunjhunwala, PM Haverty, F Gnad, ...
Genome research 22 (12), 2315-2327, 2012
A resource for cell line authentication, annotation and quality control
M Yu, SK Selvaraj, MMY Liang-Chu, S Aghajani, M Busse, J Yuan, G Lee, ...
Nature 520 (7547), 307-311, 2015
Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
LD Goldstein, J Lee, F Gnad, C Klijn, A Schaub, J Reeder, A Daemen, ...
Cell reports 16 (10), 2605-2617, 2016
A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense VariantsFunctional Analysis of BRCA1 Sequence Variants
P Bouwman, H van der Gulden, I van der Heijden, R Drost, CN Klijn, ...
Cancer discovery 3 (10), 1142-1155, 2013
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1
R Drost, KK Dhillon, H Van Der Gulden, I Van Der Heijden, I Brandsma, ...
The Journal of clinical investigation 126 (8), 2903-2918, 2016
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer
J Liu, M McCleland, EW Stawiski, F Gnad, O Mayba, PM Haverty, ...
Nature communications 5 (1), 3830, 2014
A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types
MC Wagle, D Kirouac, C Klijn, B Liu, S Mahajan, M Junttila, J Moffat, ...
NPJ precision oncology 2 (1), 7, 2018
Integration of DNA Copy Number Alterations and Prognostic Gene Expression Signatures in Breast Cancer PatientsDNA Copy Number Alterations and Prognosis
HM Horlings, C Lai, DSA Nuyten, H Halfwerk, P Kristel, E van Beers, ...
Clinical Cancer Research 16 (2), 651-663, 2010
Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data
C Klijn, H Holstege, J de Ridder, X Liu, M Reinders, J Jonkers, L Wessels
Nucleic acids research 36 (2), e13-e13, 2008
Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma
SM Kas, JR De Ruiter, K Schipper, S Annunziato, E Schut, S Klarenbeek, ...
Nature genetics 49 (8), 1219-1230, 2017
A Preclinical Mouse Model of Invasive Lobular Breast Cancer MetastasisA Preclinical Mouse Model of Breast Cancer Metastasis
CW Doornebal, S Klarenbeek, TM Braumuller, CN Klijn, M Ciampricotti, ...
Cancer research 73 (1), 353-363, 2013
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer
C Bowman-Colin, B Xia, S Bunting, C Klijn, R Drost, P Bouwman, ...
Proceedings of the National Academy of Sciences 110 (21), 8632-8637, 2013
Pharmacological induction of RAS-GTP confers RAF inhibitor sensitivity in KRAS mutant tumors
I Yen, F Shanahan, M Merchant, C Orr, T Hunsaker, M Durk, H La, ...
Cancer Cell 34 (4), 611-625. e7, 2018
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors
TJ Hagenbeek, JD Webster, NM Kljavin, MT Chang, T Pham, HJ Lee, ...
Science signaling 11 (547), eaaj1757, 2018
High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors
MJ Koudijs, C Klijn, L van der Weyden, J Kool, J ten Hoeve, D Sie, ...
Genome Research 21 (12), 2181-2189, 2011
Specific genomic aberrations in primary colorectal cancer are associated with liver metastases
SC Bruin, C Klijn, GJ Liefers, LM Braaf, SA Joosse, EH Van Beers, ...
BMC cancer 10, 1-12, 2010
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