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Leif Carlsson
Leif Carlsson
PhD
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional …
WS Redfern, L Carlsson, AS Davis, WG Lynch, IL MacKenzie, ...
Cardiovascular research 58 (1), 32-45, 2003
16872003
Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic
LM Hondeghem, L Carlsson, G Duker
Circulation 103 (15), 2004-2013, 2001
6012001
Innovative approaches to anti-arrhythmic drug therapy
S Nattel, L Carlsson
Nature reviews Drug discovery 5 (12), 1034-1049, 2006
2792006
QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions
L Carlsson, O Almgren, G Duker
Journal of cardiovascular pharmacology 16 (2), 276-285, 1990
2751990
Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations
L Carlsson, C Abrahamsson, B Andersson, G Duker, G Schiller-Linhardt
Cardiovascular Research 27 (12), 2186-2193, 1993
2471993
Novel molecular targets for atrial fibrillation therapy
D Dobrev, L Carlsson, S Nattel
Nature reviews Drug discovery 11 (4), 275-291, 2012
2232012
Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential?
L Carlsson, GJ Amos, B Andersson, L Drews, G Duker, G Wadstedt
Journal of Pharmacology and Experimental Therapeutics 282 (1), 220-227, 1997
2111997
Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
LM Gan, M Lagerström-Fermér, LG Carlsson, C Arfvidsson, AC Egnell, ...
Nature communications 10 (1), 871, 2019
1862019
Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization.
L Carlsson, C Abrahamsson, L Drews, G Duker
Circulation 85 (4), 1491-1500, 1992
1621992
Biocompatible, purified VEGF-A mRNA improves cardiac function after intracardiac injection 1 week post-myocardial infarction in swine
L Carlsson, JC Clarke, C Yen, F Gregoire, T Albery, M Billger, AC Egnell, ...
Molecular Therapy-Methods & Clinical Development 9, 330-346, 2018
1582018
Protective effects of ticagrelor on myocardial injury after infarction
G Vilahur, M Gutiérrez, L Casani, L Varela, A Capdevila, G Pons-Lladó, ...
Circulation 134 (22), 1708-1719, 2016
1422016
Azd7009: a new antiarrhythmic drug with predominant effects on the atria effectively terminates and prevents reinduction of atrial fibrillation and flutter in the sterile …
RN Goldstein, C Khrestian, L Carlsson, AL Waldo
Journal of cardiovascular electrophysiology 15 (12), 1444-1450, 2004
1192004
Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey
TG Hammond, L Carlsson, AS Davis, WG Lynch, I MacKenzie, ...
Cardiovascular Research 49 (4), 741-750, 2001
1192001
Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing
N Sun, B Ning, KM Hansson, AC Bruce, SA Seaman, C Zhang, M Rikard, ...
Scientific reports 8 (1), 17509, 2018
1032018
Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation
A Burashnikov, JM Di Diego, S Sicouri, M Ferreiro, L Carlsson, ...
Heart Rhythm 5 (12), 1735-1742, 2008
912008
In vitro and in vivo models for testing arrhythmogenesis in drugs
L Carlsson
Journal of internal medicine 259 (1), 70-80, 2006
912006
Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant
C Abrahamsson, M Palmer, B Ljung, G Duker, C Bäärnhielm, L Carlsson, ...
Cardiovascular research 28 (3), 337-344, 1994
811994
Blocking characteristics of hERG, hNav1. 5, and hKvLQT1/hminK after administration of the novel anti‐arrhythmic compound AZD7009
F Persson, L Carlsson, G Duker, I Jacobson
Journal of cardiovascular electrophysiology 16 (3), 329-341, 2005
762005
Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit
I Jacobson, L Carlsson, G Duker
Journal of pharmacological and toxicological methods 63 (1), 40-46, 2011
652011
Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre
F Persson, B Andersson, G Duker, I Jacobson, L Carlsson
European journal of pharmacology 558 (1-3), 133-143, 2007
652007
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Articles 1–20