| Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants A Quintas, DC Vaz, I Cardoso, MJM Saraiva, RMM Brito Journal of Biological Chemistry 276 (29), 27207-27213, 2001 | 391 | 2001 |
| Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine RMM Brito, WLC Vaz Analytical biochemistry 152 (2), 250-255, 1986 | 247 | 1986 |
| The tetrameric protein transthyretin dissociates to a non-native monomer in solution: a novel model for amyloidogenesis A Quintas, MJM Saraiva, RMM Brito Journal of Biological Chemistry 274 (46), 32943-32949, 1999 | 200 | 1999 |
| The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution A Quintas, MJM Saraiva, RMM Brito Febs Letters 418 (3), 297-300, 1997 | 124 | 1997 |
| Structure and aggregation mechanisms in amyloids ZL Almeida, RMM Brito Molecules 25 (5), 1195, 2020 | 108 | 2020 |
| The saposin-like domain of the plant aspartic proteinase precursor is a potent inducer of vesicle leakage C Egas, N Lavoura, R Resende, RMM Brito, E Pires, MCP de Lima, ... Journal of Biological Chemistry 275 (49), 38190-38196, 2000 | 96 | 2000 |
| Structural characterization of the minimal segment of TDP-43 competent for aggregation M Mompeán, E Buratti, C Guarnaccia, RMM Brito, A Chakrabartty, ... Archives of biochemistry and biophysics 545, 53-62, 2014 | 81 | 2014 |
| Mining approximate motifs in time series PG Ferreira, PJ Azevedo, CG Silva, RMM Brito Discovery Science: 9th International Conference, DS 2006, Barcelona, Spain …, 2006 | 72 | 2006 |
| Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA OA Chaves, CSH Jesus, PF Cruz, CMR Sant'Anna, RMM Brito, C Serpa Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 169, 175-181, 2016 | 70 | 2016 |
| Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I, GMC Gasmi-Seabrook, JW Howarth, N Finley, E Abusamhadneh, ... Biochemistry 38 (26), 8313-8322, 1999 | 70 | 1999 |
| Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin VL Shnyrov, E Villar, GG Zhadan, JM Sanchez-Ruiz, A Quintas, ... Biophysical Chemistry 88 (1-3), 61-67, 2000 | 63 | 2000 |
| Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of Interleukin‐4 DC Vaz, JR Rodrigues, W Sebald, CM Dobson, RMM Brito Protein science 15 (1), 33-44, 2006 | 58 | 2006 |
| The low-affinity Ca2 (+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction. HL Sweeney, RM Brito, PR Rosevear, JA Putkey Proceedings of the National Academy of Sciences 87 (24), 9538-9542, 1990 | 57 | 1990 |
| A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model TQ Faria, ZL Almeida, PF Cruz, CSH Jesus, P Castanheira, RMM Brito Physical Chemistry Chemical Physics 17 (11), 7255-7263, 2015 | 53 | 2015 |
| Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel CA Harley, CSH Jesus, R Carvalho, RMM Brito, JH Morais-Cabral PloS one 7 (3), e32654, 2012 | 52 | 2012 |
| A serpin released by an entomopathogen impairs clot formation in insect defense system D Toubarro, MM Avila, YJ Hao, N Balasubramanian, Y Jing, R Montiel, ... PloS one 8 (7), e69161, 2013 | 48 | 2013 |
| Ligand-targeted delivery of photosensitizers for cancer treatment P Gierlich, AI Mata, C Donohoe, RMM Brito, MO Senge, ... Molecules 25 (22), 5317, 2020 | 46 | 2020 |
| Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding GA Krudy, RMM Brito, JA Putkey, PR Rosevear Biochemistry 31 (6), 1595-1602, 1992 | 46 | 1992 |
| The apoptogenic toxin AIP56 is a metalloprotease AB toxin that cleaves NF-κb P65 DS Silva, LMG Pereira, AR Moreira, F Ferreira-da-Silva, RM Brito, ... PLoS pathogens 9 (2), e1003128, 2013 | 45 | 2013 |
| Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: insights from molecular dynamics simulations JR Rodrigues, CJV Simőes, CG Silva, RMM Brito Protein science 19 (2), 202-219, 2010 | 44 | 2010 |
