Pierre-Alain Carrupt
Pierre-Alain Carrupt
Indépendant (Chamoson), Chargé de cours (EPFL), Professeur de pharmacochimie (EPGL)
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Molecular fields in quantitative structure–permeation relationships: the VolSurf approach
G Cruciani, P Crivori, PA Carrupt, B Testa
Journal of Molecular Structure: THEOCHEM 503 (1-2), 17-30, 2000
Predicting blood− brain barrier permeation from three-dimensional molecular structure
P Crivori, G Cruciani, PA Carrupt, B Testa
Journal of medicinal chemistry 43 (11), 2204-2216, 2000
Drug–protein binding: a critical review of analytical tools
K Vuignier, J Schappler, JL Veuthey, PA Carrupt, S Martel
Analytical and bioanalytical chemistry 398, 53-66, 2010
Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase
C Brühlmann, F Ooms, PA Carrupt, B Testa, M Catto, F Leonetti, ...
Journal of medicinal chemistry 44 (19), 3195-3198, 2001
HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
C Simões-Pires, V Zwick, A Nurisso, E Schenker, PA Carrupt, M Cuendet
Molecular neurodegeneration 8 (1), 1-16, 2013
Molecular lipophilicity potential, a tool in 3D QSAR: method and applications
P Gaillard, PA Carrupt, B Testa, A Boudon
Journal of computer-aided molecular design 8, 83-96, 1994
Stereoselective Block of hERG Channel by (S)‐Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers
CB Eap, S Crettol, JS Rougier, J Schläpfer, L Sintra Grilo, JJ Déglon, ...
Clinical Pharmacology & Therapeutics 81 (5), 719-728, 2007
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs
C Gnerre, M Catto, F Leonetti, P Weber, PA Carrupt, C Altomare, A Carotti, ...
Journal of medicinal chemistry 43 (25), 4747-4758, 2000
The influence of lipophilicity on the pharmacokinetic behavior of drugs: Concepts and examples
B Testa, P Crivori, M Reist, PA Carrupt
Perspectives in Drug Discovery and Design 19, 179-211, 2000
Structure–property relationships of trimetazidine derivatives and model compounds as potential antioxidants
J Ancerewicz, E Migliavacca, PA Carrupt, B Testa, F Brée, R Zini, ...
Free Radical Biology and Medicine 25 (1), 113-120, 1998
Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity
PA Carrupt, B Testa, A Bechalany, N El Tayar, P Descas, D Perrissoud
Journal of medicinal chemistry 34 (4), 1272-1275, 1991
Monoamine oxidase inhibition by Rhodiola rosea L. roots
D Van Diermen, A Marston, J Bravo, M Reist, PA Carrupt, K Hostettmann
Journal of ethnopharmacology 122 (2), 397-401, 2009
Antimitotic and antiproliferative activities of chalcones: forward structure–activity relationship
A Boumendjel, J Boccard, PA Carrupt, E Nicolle, M Blanc, A Geze, ...
Journal of medicinal chemistry 51 (7), 2307-2310, 2008
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability
G Ottaviani, S Martel, PA Carrupt
Journal of medicinal chemistry 49 (13), 3948-3954, 2006
Percutaneous penetration of drugs: a quantitative structure‐permeability relationship study
NE Tayar, RS Tsai, B Testa, PA Carrupt, C Hansch, A Leo
Journal of pharmaceutical sciences 80 (8), 744-749, 1991
Partitioning of solutes in different solvent systems: the contribution of hydrogen-bonding capacity and polarity
N El Tayar, RS Tsai, B Testa, PA Carrupt, A Leo
Journal of pharmaceutical sciences 80 (6), 590-598, 1991
Lipophilicity in molecular modeling
B Testa, PA Carrupt, P Gaillard, F Billois, P Weber
Pharmaceutical research 13, 335-343, 1996
Liposome/water lipophilicity: methods, information content, and pharmaceutical applications
GP van Balen, CM Martinet, G Caron, G Bouchard, M Reist, PA Carrupt, ...
Medicinal research reviews 24 (3), 299-324, 2004
Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
M Reist, PA Carrupt, E Francotte, B Testa
Chemical research in toxicology 11 (12), 1521-1528, 1998
Lipophilicity profiles of ampholytes
A Pagliara, PA Carrupt, G Caron, P Gaillard, B Testa
Chemical reviews 97 (8), 3385-3400, 1997
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