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Gabriel Piedrafita
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The widespread role of non-enzymatic reactions in cellular metabolism
MA Keller, G Piedrafita, M Ralser
Current opinion in biotechnology 34, 153-161, 2015
1532015
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium
B Colom, MP Alcolea, G Piedrafita, MWJ Hall, A Wabik, SC Dentro, ...
Nature genetics 52 (6), 604-614, 2020
1152020
Mutant clones in normal epithelium outcompete and eliminate emerging tumours
B Colom, A Herms, MWJ Hall, SC Dentro, C King, RK Sood, MP Alcolea, ...
Nature 598 (7881), 510-514, 2021
1082021
Outcompeting p53-mutant cells in the normal esophagus by redox manipulation
D Fernandez-Antoran, G Piedrafita, K Murai, SH Ong, A Herms, C Frezza, ...
Cell stem cell 25 (3), 329-341. e6, 2019
992019
The impact of non-enzymatic reactions and enzyme promiscuity on cellular metabolism during (oxidative) stress conditions
G Piedrafita, MA Keller, M Ralser
Biomolecules 5 (3), 2101-2122, 2015
992015
Epidermal tissue adapts to restrain progenitors carrying clonal p53 mutations
K Murai, G Skrupskelyte, G Piedrafita, M Hall, V Kostiou, SH Ong, T Nagy, ...
Cell stem cell 23 (5), 687-699. e8, 2018
862018
A simple self-maintaining metabolic system: robustness, autocatalysis, bistability
G Piedrafita, F Montero, F Moran, ML Cardenas, A Cornish-Bowden
PLoS computational biology 6 (8), e1000872, 2010
772010
A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice
G Piedrafita, V Kostiou, A Wabik, B Colom, D Fernandez-Antoran, ...
Nature communications 11 (1), 1429, 2020
652020
Allele-specific gene expression is widespread across the genome and biological processes
R Palacios, E Gazave, J Goni, G Piedrafita, O Fernando, A Navarro, ...
PLoS One 4 (1), e4150, 2009
632009
Nonenzymatic gluconeogenesis-like formation of fructose 1, 6-bisphosphate in ice
CB Messner, PC Driscoll, G Piedrafita, MFL De Volder, M Ralser
Proceedings of the National Academy of Sciences 114 (28), 7403-7407, 2017
552017
Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution
G Piedrafita, PA Monnard, F Mavelli, K Ruiz-Mirazo
Scientific reports 7 (1), 3141, 2017
332017
Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach
G Piedrafita, K Ruiz-Mirazo, PA Monnard, A Cornish-Bowden, F Montero
PLos one 7 (6), e39480, 2012
332012
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
E Abby, SC Dentro, MWJ Hall, JC Fowler, SH Ong, R Sood, A Herms, ...
Nature Genetics 55 (2), 232-245, 2023
322023
Size matters: influence of stochasticity on the self-maintenance of a simple model of metabolic closure
G Piedrafita, A Cornish-Bowden, F Morán, F Montero
Journal of theoretical biology 300, 143-151, 2012
172012
Simulating a model of metabolic closure
A Cornish-Bowden, G Piedrafita, F Morán, ML Cárdenas, F Montero
Biological Theory 8, 383-390, 2013
162013
Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure
G Piedrafita, SJ Varma, C Castro, CB Messner, L Szyrwiel, JL Griffin, ...
PLoS Biology 19 (12), e3001468, 2021
152021
Stochastic simulations of mixed-lipid compartments: from self-assembling vesicles to self-producing protocells
K Ruiz-Mirazo, G Piedrafita, F Ciriaco, F Mavelli
Software Tools and Algorithms for Biological Systems, 689-696, 2011
132011
Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis
VR Senthivel, M Sturrock, G Piedrafita, M Isalan
Scientific Reports 6 (1), 39178, 2016
82016
Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus
A Herms, B Colom, G Piedrafita, K Murai, SH Ong, D Fernandez-Antoran, ...
bioRxiv, 2021.05. 28.446104, 2021
62021
On the transition from prebiotic to proto-biological membranes: from ‘self-assembly’to ‘self-production’
G Piedrafita, F Mavelli, F Morán, K Ruiz-Mirazo
Advances in Artificial Life. Darwin Meets von Neumann: 10th European …, 2011
62011
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Articles 1–20