Carmela Sidrauski
Carmela Sidrauski
Principal Investigator, Calico
Verified email at - Homepage
Cited by
Cited by
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
C Sidrauski, P Walter
Cell 90 (6), 1031-1039, 1997
Pharmacological brake-release of mRNA translation enhances cognitive memory
C Sidrauski, D Acosta-Alvear, A Khoutorsky, P Vedantham, BR Hearn, ...
elife 2, e00498, 2013
The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly
C Sidrauski, AM McGeachy, NT Ingolia, P Walter
elife 4, e05033, 2015
tRNA ligase is required for regulated mRNA splicing in the unfolded protein response
C Sidrauski, JS Cox, P Walter
Cell 87 (3), 405-413, 1996
The unfolded protein response: an intracellular signalling pathway with many surprising features
C Sidrauski, R Chapman, P Walter
Trends in cell biology 8 (6), 245-249, 1998
A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response
M Niwa, C Sidrauski, RJ Kaufman, P Walter
Cell 99 (7), 691-702, 1999
Intracellular signaling from the endoplasmic reticulum to the nucleus
R Chapman, C Sidrauski, P Walter
Annual review of cell and developmental biology 14 (1), 459-485, 1998
Mechanism of non‐spliceosomal mRNA splicing in the unfolded protein response pathway
TN Gonzalez, C Sidrauski, S Dörfler, P Walter
The EMBO journal, 1999
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
C Sidrauski, JC Tsai, M Kampmann, BR Hearn, P Vedantham, ...
elife 4, e07314, 2015
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α
GV Di Prisco, W Huang, SA Buffington, CC Hsu, PE Bonnen, AN Placzek, ...
Nature neuroscience 17 (8), 1073-1082, 2014
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
YL Wong, L LeBon, AM Basso, KL Kohlhaas, AL Nikkel, HM Robb, ...
Elife 8, e42940, 2019
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes
YL Wong, L LeBon, R Edalji, HB Lim, C Sun, C Sidrauski
Elife 7, e32733, 2018
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1
M Maurano, JM Snyder, C Connelly, J Henao-Mejia, C Sidrauski, ...
Immunity 54 (9), 1948-1960. e5, 2021
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
AS Mendez, J Alfaro, MA Morales-Soto, AC Dar, E McCullagh, K Gotthardt, ...
Elife 4, e05434, 2015
Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine
W Huang, AN Placzek, G Viana Di Prisco, S Khatiwada, C Sidrauski, ...
Elife 5, e12052, 2016
Modulators of the eIF2alpha pathway
P Walter, C Sidrauski, DA Alvear, MR Arkin, CG Wilson, KH Ang, ...
US Patent 9,708,247, 2017
Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α
AN Placzek, DL Molfese, S Khatiwada, G Viana Di Prisco, W Huang, ...
Elife 5, e12056, 2016
Sugar phosphate activation of the stress sensor eIF2B
Q Hao, JM Heo, BP Nocek, KG Hicks, VS Stoll, C Remarcik, S Hackett, ...
Nature communications 12 (1), 3440, 2021
Structure–Activity Studies of Bis‐O‐Arylglycolamides: Inhibitors of the Integrated Stress Response
BR Hearn, P Jaishankar, C Sidrauski, JC Tsai, P Vedantham, ...
ChemMedChem 11 (8), 870-880, 2016
The unfolded protein response
C Sidrauski, JH Brickner, P Walter
Protein Targeting, Transport, and Translocation, 151-179, 2002
The system can't perform the operation now. Try again later.
Articles 1–20