The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response C Sidrauski, P Walter Cell 90 (6), 1031-1039, 1997 | 1133 | 1997 |
Pharmacological brake-release of mRNA translation enhances cognitive memory C Sidrauski, D Acosta-Alvear, A Khoutorsky, P Vedantham, BR Hearn, ... elife 2, e00498, 2013 | 696 | 2013 |
The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly C Sidrauski, AM McGeachy, NT Ingolia, P Walter elife 4, e05033, 2015 | 621 | 2015 |
tRNA ligase is required for regulated mRNA splicing in the unfolded protein response C Sidrauski, JS Cox, P Walter Cell 87 (3), 405-413, 1996 | 543 | 1996 |
The unfolded protein response: an intracellular signalling pathway with many surprising features C Sidrauski, R Chapman, P Walter Trends in cell biology 8 (6), 245-249, 1998 | 362 | 1998 |
A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response M Niwa, C Sidrauski, RJ Kaufman, P Walter Cell 99 (7), 691-702, 1999 | 360 | 1999 |
Intracellular signaling from the endoplasmic reticulum to the nucleus R Chapman, C Sidrauski, P Walter Annual review of cell and developmental biology 14 (1), 459-485, 1998 | 331 | 1998 |
Mechanism of non‐spliceosomal mRNA splicing in the unfolded protein response pathway TN Gonzalez, C Sidrauski, S Dörfler, P Walter The EMBO journal, 1999 | 282 | 1999 |
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response C Sidrauski, JC Tsai, M Kampmann, BR Hearn, P Vedantham, ... elife 4, e07314, 2015 | 271 | 2015 |
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α GV Di Prisco, W Huang, SA Buffington, CC Hsu, PE Bonnen, AN Placzek, ... Nature neuroscience 17 (8), 1073-1082, 2014 | 206 | 2014 |
eIF2B activator prevents neurological defects caused by a chronic integrated stress response YL Wong, L LeBon, AM Basso, KL Kohlhaas, AL Nikkel, HM Robb, ... Elife 8, e42940, 2019 | 195 | 2019 |
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes YL Wong, L LeBon, R Edalji, HB Lim, C Sun, C Sidrauski Elife 7, e32733, 2018 | 124 | 2018 |
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1 M Maurano, JM Snyder, C Connelly, J Henao-Mejia, C Sidrauski, ... Immunity 54 (9), 1948-1960. e5, 2021 | 92 | 2021 |
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic AS Mendez, J Alfaro, MA Morales-Soto, AC Dar, E McCullagh, K Gotthardt, ... Elife 4, e05434, 2015 | 67 | 2015 |
Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine W Huang, AN Placzek, G Viana Di Prisco, S Khatiwada, C Sidrauski, ... Elife 5, e12052, 2016 | 61 | 2016 |
Modulators of the eIF2alpha pathway P Walter, C Sidrauski, DA Alvear, MR Arkin, CG Wilson, KH Ang, ... US Patent 9,708,247, 2017 | 34 | 2017 |
Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α AN Placzek, DL Molfese, S Khatiwada, G Viana Di Prisco, W Huang, ... Elife 5, e12056, 2016 | 27 | 2016 |
Sugar phosphate activation of the stress sensor eIF2B Q Hao, JM Heo, BP Nocek, KG Hicks, VS Stoll, C Remarcik, S Hackett, ... Nature communications 12 (1), 3440, 2021 | 22 | 2021 |
Structure–Activity Studies of Bis‐O‐Arylglycolamides: Inhibitors of the Integrated Stress Response BR Hearn, P Jaishankar, C Sidrauski, JC Tsai, P Vedantham, ... ChemMedChem 11 (8), 870-880, 2016 | 17 | 2016 |
The unfolded protein response C Sidrauski, JH Brickner, P Walter Protein Targeting, Transport, and Translocation, 151-179, 2002 | 15 | 2002 |