Nathan Alder
Nathan Alder
Professor of Molecular and Cell Biology, University of Connecticut
Verified email at - Homepage
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The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum
NN Alder, Y Shen, JL Brodsky, LM Hendershot, AE Johnson
The Journal of cell biology 168 (3), 389-399, 2005
A detergent-free strategy for the reconstitution of active enzyme complexes from native biological membranes into nanoscale discs
AR Long, CC O’Brien, K Malhotra, CT Schwall, AD Albert, A Watts, ...
BMC biotechnology 13, 1-10, 2013
Cotranslational membrane protein biogenesis at the endoplasmic reticulum
NN Alder, AE Johnson
Journal of Biological Chemistry 279 (22), 22787-22790, 2004
Energetics of protein transport across biological membranes: a study of the thylakoid ΔpH-dependent/cpTat pathway
NN Alder, SM Theg
Cell 112 (2), 231-242, 2003
The stability and activity of respiratory Complex II is cardiolipin-dependent
CT Schwall, VL Greenwood, NN Alder
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1817 (9), 1588-1596, 2012
Unremodeled and remodeled cardiolipin are functionally indistinguishable in yeast
MG Baile, M Sathappa, YW Lu, E Pryce, K Whited, JM McCaffery, X Han, ...
Journal of Biological Chemistry 289 (3), 1768-1778, 2014
Fluorescence mapping of mitochondrial TIM23 complex reveals a water-facing, substrate-interacting helix surface
NN Alder, RE Jensen, AE Johnson
Cell 134 (3), 439-450, 2008
Targeting mitochondria with methylene blue protects mice against acetaminophen‐induced liver injury
KK Lee, N Imaizumi, SR Chamberland, NN Alder, UA Boelsterli
Hepatology 61 (1), 326-336, 2015
The ionization properties of cardiolipin and its variants in model bilayers
M Sathappa, NN Alder
Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (6), 1362-1372, 2016
Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction
MS Hwang, CT Schwall, E Pazarentzos, C Datler, NN Alder, S Grimm
Cell Death & Differentiation 21 (11), 1733-1745, 2014
Mechanism of amylin fibrillization enhancement by heparin
S Jha, SM Patil, J Gibson, CE Nelson, NN Alder, AT Alexandrescu
Journal of Biological Chemistry 286 (26), 22894-22904, 2011
Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function
E Calzada, E Avery, PN Sam, A Modak, C Wang, JM McCaffery, X Han, ...
Nature communications 10 (1), 1432, 2019
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action
W Mitchell, EA Ng, JD Tamucci, KJ Boyd, M Sathappa, A Coscia, M Pan, ...
Journal of Biological Chemistry 295 (21), 7452-7469, 2020
Buckling under pressure: curvature-based lipid segregation and stability modulation in cardiolipin-containing bilayers
KJ Boyd, NN Alder, ER May
Langmuir 33 (27), 6937-6946, 2017
Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force
K Malhotra, M Sathappa, JS Landin, AE Johnson, NN Alder
Nature Structural & Molecular Biology 20 (8), 965-972, 2013
The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import
AJ Davis, NN Alder, RE Jensen, AE Johnson
Molecular biology of the cell 18 (2), 475-486, 2007
Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte
H Zhang, NN Alder, W Wang, H Szeto, DJ Marcinek, PS Rabinovitch
Elife 9, e60827, 2020
Green proteorhodopsin reconstituted into nanoscale phospholipid bilayers (nanodiscs) as photoactive monomers
MJ Ranaghan, CT Schwall, NN Alder, RR Birge
Journal of the American Chemical Society 133 (45), 18318-18327, 2011
Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes
KK Lee, K Fujimoto, C Zhang, CT Schwall, NN Alder, CA Pinkert, ...
Free Radical Biology and Medicine 65, 584-594, 2013
Quaternary structure of the mitochondrial TIM23 complex reveals dynamic association between Tim23p and other subunits
NN Alder, J Sutherland, AI Buhring, RE Jensen, AE Johnson
Molecular biology of the cell 19 (1), 159-170, 2008
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