Diego Acosta-Alvear
Diego Acosta-Alvear
Principal Investigator, Altos Labs, Bay Area Institute
Verified email at
Cited by
Cited by
XBP1 controls diverse cell type-and condition-specific transcriptional regulatory networks
D Acosta-Alvear, Y Zhou, A Blais, M Tsikitis, NH Lents, C Arias, ...
Molecular cell 27 (1), 53-66, 2007
Pharmacological brake-release of mRNA translation enhances cognitive memory
C Sidrauski, D Acosta-Alvear, A Khoutorsky, P Vedantham, BR Hearn, ...
elife 2, e00498, 2013
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
M Lu, DA Lawrence, S Marsters, D Acosta-Alvear, P Kimmig, AS Mendez, ...
science 345 (6192), 98-101, 2014
An initial blueprint for myogenic differentiation
A Blais, M Tsikitis, D Acosta-Alvear, R Sharan, Y Kluger, BD Dynlacht
Genes & development 19 (5), 553-569, 2005
The unfolded protein response: detecting and responding to fluctuations in the protein-folding capacity of the endoplasmic reticulum
GE Karagöz, D Acosta-Alvear, P Walter
Cold Spring Harbor perspectives in biology 11 (9), a033886, 2019
An unfolded protein-induced conformational switch activates mammalian IRE1
GE Karagöz, D Acosta-Alvear, HT Nguyen, CP Lee, F Chu, P Walter
Elife 6, e30700, 2017
Targeting IRE1 with small molecules counteracts progression of atherosclerosis
O Tufanli, P Telkoparan Akillilar, D Acosta-Alvear, B Kocaturk, UI Onat, ...
Proceedings of the National Academy of Sciences 114 (8), E1395-E1404, 2017
Retinoblastoma tumor suppressor protein–dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit
A Blais, CJC van Oevelen, R Margueron, D Acosta-Alvear, BD Dynlacht
The Journal of cell biology 179 (7), 1399-1412, 2007
A CHOP-regulated microRNA controls rhodopsin expression
S Behrman, D Acosta-Alvear, P Walter
Journal of Cell Biology 192 (6), 919-927, 2011
Validation of the Hsp70–Bag3 protein–protein interaction as a potential therapeutic target in cancer
X Li, T Colvin, JN Rauch, D Acosta-Alvear, M Kampmann, B Dunyak, ...
Molecular cancer therapeutics 14 (3), 642-648, 2015
A scalable, easy-to-deploy protocol for Cas13-based detection of SARS-CoV-2 genetic material
JN Rauch, E Valois, SC Solley, F Braig, RS Lach, M Audouard, ...
Journal of clinical microbiology 59 (4), 10.1128/jcm. 02402-20, 2021
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits
D Acosta-Alvear, MY Cho, T Wild, TJ Buchholz, AG Lerner, O Simakova, ...
elife 4, e08153, 2015
The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
D Acosta-Alvear, GE Karagöz, F Fröhlich, H Li, TC Walther, P Walter
Elife 7, e43036, 2018
Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells
DW Sherbenou, BT Aftab, Y Su, CR Behrens, A Wiita, AC Logan, ...
The Journal of clinical investigation 126 (12), 4640-4653, 2016
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
JM Harnoss, A Le Thomas, A Shemorry, SA Marsters, DA Lawrence, M Lu, ...
Proceedings of the National Academy of Sciences 116 (33), 16420-16429, 2019
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
E Dufey, JM Bravo-San Pedro, C Eggers, M González-Quiroz, H Urra, ...
Nature communications 11 (1), 2401, 2020
E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation
P Asp, D Acosta-Alvear, M Tsikitis, C Van Oevelen, BD Dynlacht
Genes & development 23 (1), 37-53, 2009
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
AS Mendez, J Alfaro, MA Morales-Soto, AC Dar, E McCullagh, K Gotthardt, ...
Elife 4, e05434, 2015
A conformational RNA zipper promotes intron ejection during non‐conventional XBP1 mRNA splicing
J Peschek, D Acosta‐Alvear, AS Mendez, P Walter
EMBO reports 16 (12), 1688-1698, 2015
The importance of naturally attenuated SARS‐CoV‐2 in the fight against COVID‐19
J Armengaud, A Delaunay‐Moisan, JY Thuret, E Van Anken, ...
Environmental microbiology 22 (6), 1997-2000, 2020
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