| IDH mutation impairs histone demethylation and results in a block to cell differentiation C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ... Nature 483 (7390), 474-478, 2012 | 1970 | 2012 |
| A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma DM O’Rourke, MLP Nasrallah, A Desai, JJ Melenhorst, K Mansfield, ... Science translational medicine 9 (399), eaaa0984, 2017 | 1237 | 2017 |
| Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial M Weller, N Butowski, DD Tran, LD Recht, M Lim, H Hirte, L Ashby, ... The Lancet Oncology 18 (10), 1373-1385, 2017 | 794 | 2017 |
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| Induction of ischemic tolerance following brief focal ischemia in rat brain SS Glazier, DM O'Rourke, DI Graham, FA Welsh Journal of Cerebral Blood Flow & Metabolism 14 (4), 545-553, 1994 | 295 | 1994 |
| Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1–independent mechanism N Pore, S Liu, HK Shu, B Li, D Haas-Kogan, D Stokoe, J Milanini-Mongiat, ... Molecular biology of the cell 15 (11), 4841-4853, 2004 | 279 | 2004 |
| Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques L Macyszyn, H Akbari, JM Pisapia, X Da, M Attiah, V Pigrish, Y Bi, S Pal, ... Neuro-oncology 18 (3), 417-425, 2015 | 278 | 2015 |
| Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo BW Park, HT Zhang, C Wu, A Berezov, X Zhang, R Dua, Q Wang, G Kao, ... Nature biotechnology 18 (2), 194-198, 2000 | 260 | 2000 |
| Intraaxial Brain Masses: MR Imaging–based Diagnostic Strategy—Initial Experience1 RN Al-Okaili, J Krejza, JH Woo, RL Wolf, DM O'Rourke, KD Judy, ... Radiology 243 (2), 539-550, 2007 | 237 | 2007 |
| Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla RL Wolf, J Wang, S Wang, ER Melhem, DM O'Rourke, KD Judy, JA Detre Journal of Magnetic Resonance Imaging: An Official Journal of the …, 2005 | 209 | 2005 |
| PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating … N Pore, S Liu, DA Haas-Kogan, DM O’Rourke, A Maity Cancer research 63 (1), 236-241, 2003 | 208 | 2003 |
| CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges SJ Bagley, AS Desai, GP Linette, CH June, DM O’Rourke Neuro-oncology 20 (11), 1429-1438, 2018 | 202 | 2018 |
| Differentiation between glioblastomas, solitary brain metastases, and primary cerebral lymphomas using diffusion tensor and dynamic susceptibility contrast-enhanced MR imaging S Wang, S Kim, S Chawla, RL Wolf, DE Knipp, A Vossough, DM O'Rourke, ... American Journal of Neuroradiology 32 (3), 507-514, 2011 | 195 | 2011 |
| Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging S Wang, S Kim, S Chawla, RL Wolf, WG Zhang, DM O'Rourke, KD Judy, ... Neuroimage 44 (3), 653-660, 2009 | 184 | 2009 |
| The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors CJ Wu, DM O'Rourke, GS Feng, GR Johnson, Q Wang, MI Greene Oncogene 20 (42), 6018-6025, 2001 | 169 | 2001 |
| Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α Q Wang, Z He, M Huang, T Liu, Y Wang, H Xu, H Duan, P Ma, L Zhang, ... Nature communications 9 (1), 559, 2018 | 166 | 2018 |
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| Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells A Ayuso-Sacido, JA Moliterno, S Kratovac, GS Kapoor, DM O’Rourke, ... Journal of neuro-oncology 97, 323-337, 2010 | 151 | 2010 |
Christos DavatzikosDirector, AI2D Center for AI/Data Science for Integrated Diagnostics, Professor Radiology/ESE/DBEIVerified email at pennmedicine.upenn.edu
