Osmany Guirola Cruz

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Luis Javier González LópezTitular Researcher, Center for Genetic Engineering and Biotechnology, Havana, CubaVerified email at cigb.edu.cu
Yassel Ramos GómezCenter for Genetic Engineering and BiotechnologyVerified email at cigb.edu.cu
vladimir besadacentro de ingeniería genética y biotecnologíaVerified email at cigb.edu.cu
Yasset Perez-RiverolTeam Coordinator, Proteomics Resources, EMBL-EBI, UKVerified email at ebi.ac.uk
Noralvis Fleitas SalazarUniversidad Católica del MauleVerified email at ucm.cl
Teresa Nuñez de Villavicencio DiazWestern UniversityVerified email at uwo.ca
Gleysin CabreraCenter for Genetic Engineering and BiotechnologyVerified email at cigb.edu.cu
Alexis YeroHarvard Medical School/Massachusetts General HospitalVerified email at mgh.harvard.edu
Alejandro MartinStaff researcher, Center for Genetic Engineering and Biotechnology, CubaVerified email at cigb.edu.cu
Julio Raúl Fernández MassóCentro de Ingeniería Genética y BiotecnologíaVerified email at cigb.edu.cu
Aniel Sanchez PuenteSenior ResearcherVerified email at northwestern.edu
Bruno DomonVerified email at crp-sante.lu
Gertrudis RojasSenior researcher and Head of the Protein Engineering Department, Center of Molecular ImmunologyVerified email at cim.sld.cu
Roberto Vera Alvarez, PhDNational Center for Biotechnology InformationVerified email at ncbi.nlm.nih.gov
Gerardo GuillenBiomedical Research Director, Center for Genética Engineering and Biotechnology, Havana, CubaaVerified email at cigb.edu.cu
Lennart MartensSenior Full Professor of Systems Biology, Ghent University and VIB, Ghent, BelgiumVerified email at UGent.be
Henning HermjakobHead of Molecular Systems, European Bioinformatics Institute (EMBL-EBI)Verified email at ebi.ac.uk
Juergen CoxMax Planck Institute of BiochemistryVerified email at biochem.mpg.de
Oliver KohlbacherProfessor for Applied Bioinformatics, University of TübingenVerified email at uni-tuebingen.de
Pedro A ValienteDonnelly Center for Cellular and Biomolecular Research, Faculty of Medicine, University of TorontoVerified email at utoronto.ca

Osmany Guirola Cruz

Center for Genetic Engineering and Biotechnology

Verified email at cigb.edu.cu

Computational Biology Drug Design Computational Chemistry Computer-aided drug design structure-based drug design


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Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody R Alonso, V Huerta, J de Leon, P Piedra, Y Puchades, O Guirola, ... Hybridoma 27 (4), 291-301, 2008	96	2008
A comparative molecular dynamics study of thermophilic and mesophilic β-fructosidase enzymes Y Mazola, O Guirola, S Palomares, G Chinea, C Menéndez, L Hernández, ... Journal of Molecular Modeling 21, 1-11, 2015	84	2015
Functional and mass spectrometric evaluation of an anti-tick antigen based on the P0 peptide conjugated to Bm86 protein A Rodríguez Mallón, L Javier González, PE Encinosa Guzmán, ... Pathogens 9 (6), 513, 2020	30	2020
Chemical compounds having antiviral activity against dengue virus and other flaviviruses YM Reyes, GC Santiago, OG Cruz, RV Alvarez, VH Galindo, NF Salazar, ... US Patent 8,722,742, 2014	28	2014
Synthesis, LC-MS/MS analysis, and biological evaluation of two vaccine candidates against ticks based on the antigenic P0 peptide from R. sanguineus linked to the p64K … LJ González, PE Encinosa Guzmán, W Machado, S Pousa, A Leyva, ... Analytical and Bioanalytical Chemistry 413, 5885-5900, 2021	27	2021
CIGB-300 anticancer peptide regulates the protein kinase CK2-dependent phosphoproteome Y Perera, Y Ramos, G Padrón, E Caballero, O Guirola, LG Caligiuri, ... Molecular and cellular biochemistry 470, 63-75, 2020	26	2020
Investigación social M De Souza, S Ferreira, O Cruz, R Gómez Teoría, método y creatividad. Buenos Aires: Lugar, 2003	25	2003
Investigacion social: teoria, metodo y creatividad MC Souza, S Ferreira, O Cruz, R Gomes Argentina: Lugar Editorial 13, 2003	24	2003
Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses GC Santiago, VH Galindo, AMM Dunn, JVG Cowley, NF Salazar, OG Cruz, ... US Patent App. 12/094,503, 2009	22	2009
Pharmacophore model of immunocheckpoint protein PD-L1 by cosolvent molecular dynamics simulations C Mejías, O Guirola Journal of Molecular Graphics and Modelling 91, 105-111, 2019	21	2019
Bioinformatics tools for the functional interpretation of quantitative proteomics results T Nunez Villavicencio-Diaz, A Rodríguez-Ulloa, O Guirola-Cruz, ... Current topics in medicinal chemistry 14 (3), 435-449, 2014	21	2014
Computational proteomics pitfalls and challenges: HavanaBioinfo 2012 workshop report Y Perez-Riverol, H Hermjakob, O Kohlbacher, L Martens, D Creasy, J Cox, ... Journal of proteomics 87, 134-138, 2013	21	2013
Novel interactions of domain III from the envelope glycoprotein of dengue 2 virus with human plasma proteins V Huerta, Y Ramos, A Yero, D Pupo, D Martín, P Toledo, N Fleitas, ... Journal of proteomics 131, 205-213, 2016	20	2016
Comparative proteomics analysis of the antitumor effect of CIGB-552 peptide in HT-29 colon adenocarcinoma cells TN de Villavicencio-Díaz, YR Gómez, BO Argüelles, JRF Masso, ... Journal of proteomics 126, 163-171, 2015	20	2015
A deeper mining on the protein composition of VA-MENGOC-BC®: An OMV-based vaccine against N. meningitidis serogroup B and C Y Masforrol, J Gil, D García, J Noda, Y Ramos, L Betancourt, O Guirola, ... Human Vaccines & Immunotherapeutics 13 (11), 2548-2560, 2017	19	2017
Receptor-activated human α₂-macroglobulin interacts with the envelope protein of dengue virus and protects virions from temperature-induced inactivation through … V Huerta, P Toledo, N Fleitas, A Martín, D Pupo, A Yero, M Sarría, ... Journal of General Virology 95 (12), 2668-2676, 2014	17	2014
Predicting CK2 beta-dependent substrates using linear patterns TN de Villavicencio-Díaz, Y Mazola, YP Negrín, YC García, OG Cruz, ... Biochemistry and biophysics reports 4, 20-27, 2015	15	2015
Isolation of a novel neutralizing antibody fragment against human vascular endothelial growth factor from a phage-displayed human antibody repertoire using an epitope … H Lamdan, M Ayala, G Rojas, Y Munoz, Y Morera, O Guirola, G Chinea, ... Journal of biotechnology 151 (2), 166-174, 2011	13	2011
Investigación social M Minayo De Souza, S Ferreira, O Cruz, R Gomes Teoría, método y creatividad. Editorial Argentina: Buenos Aires, 2003	13	2003
Method to block the infection by flaviviruses, molecules and uses VH Galindo, GC Santiago, NF Salazar, AMM Dunn, MS Nunez, OG Cruz, ... US Patent 8,420,311, 2013	11	2013

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