| Biological interpretation of genome-wide association studies using predicted gene functions TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, J Yang, JC Lui, ... Nature communications 6 (1), 5890, 2015 | 764 | 2015 |
| Distribution and medical impact of loss-of-function variants in the Finnish founder population ET Lim, P Würtz, AS Havulinna, P Palta, T Tukiainen, K Rehnström, ... PLoS genetics 10 (7), e1004494, 2014 | 409 | 2014 |
| An enhanced CRISPR repressor for targeted mammalian gene regulation NC Yeo, A Chavez, A Lance-Byrne, Y Chan, D Menn, D Milanova, ... Nature methods 15 (8), 611-616, 2018 | 342 | 2018 |
| Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder ET Lim, M Uddin, S De Rubeis, Y Chan, AS Kamumbu, X Zhang, ... Nature neuroscience 20 (9), 1217-1224, 2017 | 227 | 2017 |
| Directional dominance on stature and cognition in diverse human populations PK Joshi, T Esko, H Mattsson, N Eklund, I Gandin, T Nutile, AU Jackson, ... Nature 523 (7561), 459-462, 2015 | 178 | 2015 |
| Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses YK Chan, SK Wang, CJ Chu, DA Copland, AJ Letizia, H Costa Verdera, ... Science translational medicine 13 (580), eabd3438, 2021 | 91 | 2021 |
| High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast X Guo, A Chavez, A Tung, Y Chan, C Kaas, Y Yin, R Cecchi, SL Garnier, ... Nature biotechnology 36 (6), 540-546, 2018 | 77 | 2018 |
| Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height JC Lui, O Nilsson, Y Chan, CD Palmer, AC Andrade, JN Hirschhorn, ... Human molecular genetics 21 (23), 5193-5201, 2012 | 75 | 2012 |
| Genome-wide analysis of body proportion classifies height-associated variants by mechanism of action and implicates genes important for skeletal development Y Chan, RM Salem, YHH Hsu, G McMahon, TH Pers, S Vedantam, T Esko, ... The American Journal of Human Genetics 96 (5), 695-708, 2015 | 64 | 2015 |
| Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals Y Chan, OL Holmen, A Dauber, L Vatten, AS Havulinna, F Skorpen, ... PLoS genetics 7 (12), e1002439, 2011 | 64 | 2011 |
| An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases Y Chan, ET Lim, N Sandholm, SR Wang, AJ McKnight, S Ripke, MJ Daly, ... The American Journal of Human Genetics 94 (3), 437-452, 2014 | 46 | 2014 |
| A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity ET Lim, YP Liu, Y Chan, T Tiinamaija, AM Käräjämäki, E Madsen, ... The American Journal of Human Genetics 95 (5), 509-520, 2014 | 30 | 2014 |
| A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity ET Lim, YP Liu, Y Chan, T Tiinamaija, AM Käräjämäki, E Madsen, ... The American Journal of Human Genetics 95 (5), 509-520, 2014 | 30 | 2014 |
| Genetic Investigation of ANthropometric Traits (GIANT) Consortium Biological interpretation of genome-wide association studies using predicted gene functions TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, J Yang, JC Lui, ... Nat. Commun 6, 5890, 2015 | 25 | 2015 |
| Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun. 2015; 6: 5890 TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, J Yang, JC Lui, ... | 16 | |
| Genetic Investigation of ATC, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, J Yang, JC Lui, ... Biological interpretation of genome-wide association studies using predicted …, 2015 | 10 | 2015 |
| Enabling multiplexed testing of pooled donor cells through whole-genome sequencing Y Chan, YK Chan, DB Goodman, X Guo, A Chavez, ET Lim, GM Church Genome Medicine 10, 1-11, 2018 | 7 | 2018 |
| Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder ET Lim, Y Chan, P Dawes, X Guo, S Erdin, DJC Tai, S Liu, JM Reichert, ... Nature Communications 13 (1), 3243, 2022 | 6 | 2022 |
| Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids ET Lim, Y Chan, MJ Burns, X Guo, S Erdin, DJC Tai, JM Reichert, ... bioRxiv, 2020.11. 15.375386, 2020 | 5 | 2020 |
| Reducing AAV-mediated immune responses and pathology in a subretinal pig model by engineering the vector genome YK Chan, S Wang, A Letizia, Y Chan, E Lim, A Graveline, HC Verdera, ... Molecular Therapy 27 (4), 298-298, 2019 | 4 | 2019 |
