Subramanian Yegneswaran
Subramanian Yegneswaran
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Activated protein C variants with normal cytoprotective but reduced anticoagulant activity
LO Mosnier, AJ Gale, S Yegneswaran, JH Griffin
Blood 104 (6), 1740-1744, 2004
Endothelial protein C receptor
CT Esmon, J Xu, J Gu, D Qu, Z Laszik, G Ferrell, DJ Stearns-Kurosawa, ...
Thrombosis and haemostasis 82 (08), 251-258, 1999
Bisarylhydrazones as Exchangeable Biocompatible Linkers
A Dirksen, S Yegneswaran, PE Dawson
Angewandte Chemie (International ed. in English) 49 (11), 2023, 2010
Protein S alters the active site location of activated protein C above the membrane surface
S Yegneswaran, GM Wood, CT Esmon, AE Johnson
Journal of Biological Chemistry 272 (40), 25013-25021, 1997
Sphingolipids as bioactive regulators of thrombin generation
H Deguchi, S Yegneswaran, JH Griffin
Journal of Biological Chemistry 279 (13), 12036-12042, 2004
Relocating the active site of activated protein C eliminates the need for its protein S cofactor: a fluorescence resonance energy transfer study
S Yegneswaran, MD Smirnov, O Safa, NL Esmon, CT Esmon, ...
Journal of Biological Chemistry 274 (9), 5462-5468, 1999
Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data
H Deguchi, Y Banerjee, S Trauger, G Siuzdak, E Kalisiak, JA FernŠndez, ...
Blood, The Journal of the American Society of Hematology 126 (13), 1595-1600, 2015
Interaction of the A1 subunit of factor VIIIa and the serine protease domain of factor X identified by zero-length cross-linking
KA Lapan, PJ Fay
Thrombosis and haemostasis 80 (09), 418-422, 1998
Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex
S Yegneswaran, RM Mesters, JH Griffin
Journal of Biological Chemistry 278 (35), 33312-33318, 2003
Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S
Biochemical Journal 349 (3), 757-764, 2000
C4b-binding protein inhibits the factor V-dependent but not the factor V-independent cofactor activity of protein S in the activated protein C-mediated inactivation of factor VIIIa
RHL van de Poel, JCM Meijers, BN Bouma
Thrombosis and haemostasis 85 (05), 761-765, 2001
Topological studies of the amino terminal modules of vitamin K-dependent protein S using monoclonal antibody epitope mapping and molecular modeling
TK Giri, BO Villoutreix, A Wallqvist, B Dahlbšck, PG de Frutos
Thrombosis and haemostasis 80 (11), 798-804, 1998
Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site
AJ Gale, S Yegneswaran, X Xu, JL Pellequer, JH Griffin
Journal of Biological Chemistry 282 (30), 21848-21855, 2007
Prothrombin residues 473–487 contribute to factor Va binding in the prothrombinase complex
S Yegneswaran, RM Mesters, JA FernŠndez, JH Griffin
Journal of Biological Chemistry 279 (47), 49019-49025, 2004
Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human-and bovine-activated protein C with negatively charged phospholipid vesicles
S Yegneswaran, H Deguchi, JH Griffin
Journal of Biological Chemistry 278 (17), 14614-14621, 2003
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia
XY Zhao, A Wilmen, D Wang, X Wang, M Bauzon, JY Kim, L Linden, L Li, ...
Nature Communications 11 (1), 2992, 2020
Raising the active site of factor VIIa above the membrane surface reduces its procoagulant activity but not factor VII autoactivation
EK Waters, S Yegneswaran, JH Morrissey
Journal of Biological Chemistry 281 (36), 26062-26068, 2006
The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa
S Yegneswaran, TM Hackeng, PE Dawson, JH Griffin
Journal of Biological Chemistry 283 (48), 33046-33052, 2008
Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe
S Yegneswaran, JA FernŠndez, JH Griffin, PE Dawson
Chemistry & biology 9 (4), 485-494, 2002
FRET studies with factor X mutants provide insight into the topography of the membrane-bound factor X/Xa
SH Qureshi, L Yang, S Yegneswaran, AR Rezaie
Biochemical Journal 407 (3), 427-433, 2007
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