Sjoerd Klarenbeek
Sjoerd Klarenbeek
Veterinary pathologist, Netherlands Cancer Institute
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BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
R Drost, P Bouwman, S Rottenberg, U Boon, E Schut, S Klarenbeek, ...
Cancer cell 20 (6), 797-809, 2011
Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland
S Annunziato, SM Kas, M Nethe, H Yücel, J Del Bravo, C Pritchard, RB Ali, ...
Genes & development 30 (12), 1470-1480, 2016
Expression of receptors for luteinizing hormone, gastric-inhibitory polypeptide, and vasopressin in normal adrenal glands and cortisol-secreting adrenocortical tumors in dogs
S Galac, VJ Kars, S Klarenbeek, KJ Teerds, JA Mol, HS Kooistra
Domestic animal endocrinology 39 (1), 63-75, 2010
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1
R Drost, KK Dhillon, H Van Der Gulden, I Van Der Heijden, I Brandsma, ...
The Journal of clinical investigation 126 (8), 2903-2918, 2016
Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma
SM Kas, JR De Ruiter, K Schipper, S Annunziato, E Schut, S Klarenbeek, ...
Nature genetics 49 (8), 1219-1230, 2017
A Preclinical Mouse Model of Invasive Lobular Breast Cancer MetastasisA Preclinical Mouse Model of Breast Cancer Metastasis
CW Doornebal, S Klarenbeek, TM Braumuller, CN Klijn, M Ciampricotti, ...
Cancer research 73 (1), 353-363, 2013
XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data
RJC Kluin, K Kemper, T Kuilman, JR de Ruiter, V Iyer, JV Forment, ...
BMC bioinformatics 19 (1), 1-15, 2018
PTEN loss in E-cadherin-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma
MC Boelens, M Nethe, S Klarenbeek, JR de Ruiter, E Schut, N Bonzanni, ...
Cell reports 16 (8), 2087-2101, 2016
Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours
JM Fernandes Neto, E Nadal, E Bosdriesz, SN Ooft, L Farre, C McLean, ...
Nature communications 11 (1), 3157, 2020
Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor SignalingLoss of p120 Leads to …
RCJ Schackmann, S Klarenbeek, EJ Vlug, S Stelloo, M Van Amersfoort, ...
Cancer research 73 (15), 4937-4949, 2013
Cross-species comparison of aCGH data from mouse and human BRCA1-and BRCA2-mutated breast cancers
H Holstege, E van Beers, A Velds, X Liu, SA Joosse, S Klarenbeek, ...
BMC cancer 10 (1), 1-16, 2010
Effect of growth-promoting 17β-estradiol, 19-nortestosterone and dexamethasone on circulating levels of nine potential biomarker candidates in veal calves
G Cacciatore, SWF Eisenberg, C Situ, MH Mooney, P Delahaut, ...
Analytica chimica acta 637 (1-2), 351-359, 2009
Genetically engineered mouse models of PI3K signaling in breast cancer
S Klarenbeek, MH van Miltenburg, J Jonkers
Molecular oncology 7 (2), 146-164, 2013
Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547Resistance Mechanisms to FGFR-Targeted Therapy in ILC
SM Kas, JR De Ruiter, K Schipper, E Schut, L Bombardelli, E Wientjens, ...
Cancer Research 78 (19), 5668-5679, 2018
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma
H Vlaming, CM McLean, T Korthout, MF Alemdehy, S Hendriks, C Lancini, ...
The EMBO Journal 38 (14), e101564, 2019
Somatic structural rearrangements in genetically engineered mouse mammary tumors
I Varela, C Klijn, PJ Stephens, LJ Mudie, L Stebbings, D Galappaththige, ...
Genome biology 11 (10), 1-12, 2010
Influence of 17β-oestradiol, nortestosterone and dexamethasone on the adaptive immune response in veal calves
SWF Eisenberg, G Cacciatore, S Klarenbeek, AA Bergwerff, AP Koets
Research in veterinary science 84 (2), 199-205, 2008
Reducing chloride conductance prevents hyperkalaemia‐induced loss of twitch force in rat slow‐twitch muscle
MG Van Emst, S Klarenbeek, A Schot, JJ Plomp, A Doornenbal, ...
The Journal of Physiology 561 (1), 169-181, 2004
Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation
M Van Miltenburg, MJ Van Nimwegen, I Tijdens, R Lalai, R Kuiper, ...
British journal of cancer 110 (11), 2747-2755, 2014
p120-catenin is critical for the development of invasive lobular carcinoma in mice
M Tenhagen, S Klarenbeek, TM Braumuller, I Hofmann, P van der Groep, ...
Journal of Mammary Gland Biology and Neoplasia 21, 81-88, 2016
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