Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects NN Jiménez-Vargas, Y Yu, DD Jensen, DD Bok, M Wisdom, R Latorre, ... Gut 71 (4), 695-704, 2022 | 33 | 2022 |
Cannabinoid 1 and mu-opioid receptor agonists synergistically inhibit abdominal pain and lack side effects in mice Y Yu, QK Tsang, J Jaramillo-Polanco, AE Lomax, SJ Vanner, DE Reed Journal of Neuroscience 42 (33), 6313-6324, 2022 | 14 | 2022 |
Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain CJ Tuck, AA Omar, G De Palma, S Osman, NN Jiménez-Vargas, Y Yu, ... Gut 72 (9), 1678-1691, 2023 | 9 | 2023 |
Dietary monosodium glutamate increases visceral hypersensitivity in a mouse model of visceral pain BJA Brant, Y Yu, AA Omar, JO Jaramillo Polanco, CD Lopez Lopez, ... Neurogastroenterology & Motility 35 (9), e14596, 2023 | 3 | 2023 |
A124 synergistic interaction of cannabinoids and opioids reduces pain signaling in colonic nociceptive nerves Q Tsang, Y Yu, AE Lomax, S Vanner, DE Reed Journal of the Canadian Association of Gastroenterology 3 (Supplement_1 …, 2020 | 2 | 2020 |
A53 a novel ph-sensitive opioid analogue provides sustained analgesia during colonic inflammation and lacks common side effects CE Degro, NN Jiménez-Vargas, QK Tsang, Y Yu, C Stein, NW Bunnett, ... Journal of the Canadian Association of Gastroenterology 5 (Suppl 1), 61, 2022 | 1 | 2022 |
A10 FOOD ANTIGEN-STRESS INTERACTION LEADS TO INCREASE PAIN SIGNALING IN ILEUM AND COLON VIA STAT6 IN AN IBS MODEL C Lopez Lopez, J Jaramillo Polanco, Y Yu, QK Tsang, S Vanner, ... Journal of the Canadian Association of Gastroenterology 4 (Supplement_1), 11-12, 2021 | 1 | 2021 |
A45 a novel PH-sensitive opioid analgesic that selectively inhibits nociception in DSS-induced colitis Y Yu, NN Jiménez-Vargas, QK Tsang, C Lopez Lopez, ... Journal of the Canadian Association of Gastroenterology 4 (Supplement_1 …, 2021 | 1 | 2021 |
393 Cannabinoids and opioids synergistically inhibit mouse colonic nociceptive signaling via nitric oxide Y Yu, Q Tsang, AE Lomax, S Vanner, DE Reed Gastroenterology 158 (6), S-71, 2020 | 1 | 2020 |
322 CANNABINOID 1 RECEPTOR SIGNALING IN COLONIC NOCICPETION IS ALTERED BY CHANGES OF THE ENDOCANNABINOID SYSTEM DURING COLITIS QK Tsang, M Kaufmann, AE Lomax, S Vanner, DE Reed Gastroenterology 166 (5), S-72, 2024 | | 2024 |
Protease-Induced Excitation of Dorsal Root Ganglion Neurons in Response to Acute Perturbation of the Gut Microbiota Is Associated With Visceral and Somatic Hypersensitivity CC Baker, JL Sessenwein, HM Wood, Y Yu, Q Tsang, TA Alward, ... Cellular and Molecular Gastroenterology and Hepatology, 2024 | | 2024 |
A7 CANNABINOID 1 AND 2 RECEPTOR AGONISTS AND MU-OPIOID RECEPTOR AGONISTS SYNERGISTICALLY INHIBIT COLONIC NOCICEPTION DURING ACUTE COLITIS QK Tsang, AE Lomax, S Vanner, DE Reed Journal of the Canadian Association of Gastroenterology 7 (Supplement_1), 4-5, 2024 | | 2024 |
Sa1232 NOVEL PH-SENSITIVE OPIOID DOES NOT INDUCE TOLERANCE IN A COLITIS MOUSE MODEL NN Jiménez-Vargas, CE Degro, QK Tsang, M Guzman-Rodriguez, ... Gastroenterology 164 (6), S-333, 2023 | | 2023 |
Sa1757 CANNABINOID AND OPIOID RECEPTOR SIGNALING IN COLONIC NOCICEPTORS IS MARKEDLY ALTERED BY ACUTE COLITIS QK Tsang, HM Schincariol, CE Degro, AE Lomax, S Vanner, DE Reed Gastroenterology 164 (6), S-419, 2023 | | 2023 |
A2 ACUTE COLITIS CAUSES CHANGES TO THE EFFICACY OF CANNABINOID-1 AND MU-OPIOID RECEPTOR AGONISTS ON INHIBITING ABDOMINAL PAIN QK Tsang, CE Degro, HM Schincariol, AE Lomax, SJ Vanner, DE Reed Journal of the Canadian Association of Gastroenterology 6 (Suppl 1), 1, 2023 | | 2023 |
A277 A NOVEL PH-SENSITIVE Μ-OPIOID RECEPTOR AGONIST THAT DOES NOT INDUCE TOLERANCE IN A COLITIS MOUSE MODEL CE Degro, NN Jiménez-Vargas, HM Schincariol, QK Tsang, ... Journal of the Canadian Association of Gastroenterology 6 (Supplement_1), 90-91, 2023 | | 2023 |
A283 ROLE OF IMMUNOGLOBULIN E IN ABDOMINAL PAIN DUE TO INTERACTIONS BETWEEN DIET AND STRESS IN A MODEL OF IBS C Lopez Lopez, J Jaramillo Polanco, QK Tsang, AE Lomax, SJ Vanner, ... Journal of the Canadian Association of Gastroenterology 6 (Supplement_1), 94-95, 2023 | | 2023 |
Evolving acidic microenvironments during colitis provide selective analgesic targets for a pH-sensitive opioid CE Degro, NN Jiménez-Vargas, Q Tsang, Y Yu, M Guzman-Rodriguez, ... Pain, 10.1097, 2022 | | 2022 |
242: A NOVEL PH-SENSITIVE OPIOID PROVIDES SUSTAINED ANALGESIA DURING COLONIC INFLAMMATION AND LACKS COMMON SIDE EFFECTS NN Jiménez-Vargas, CE Degro, QK Tsang, Y Yu, C Stein, NW Bunnett, ... Gastroenterology 162 (7), S-49, 2022 | | 2022 |
A239 COMBINED CANNABINOID RECEPTOR 1 AND MU-OPIOID RECEPTOR AGONISTS SYNERGISTICALLY INHIBIT VISCERAL PAIN IN VIVO WITHOUT … QK Tsang, Y Yu, AE Lomax, S Vanner, DE Reed Journal of the Canadian Association of Gastroenterology 5 (Supplement_1 …, 2022 | | 2022 |