Chao Zhang
Chao Zhang
Professor of Chemistry, University of Southern California
Verified email at
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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
PI Poulikakos, C Zhang, G Bollag, KM Shokat, N Rosen
Nature 464 (7287), 427-430, 2010
IRE1 signaling affects cell fate during the unfolded protein response
JH Lin, H Li, D Yasumura, HR Cohen, C Zhang, B Panning, KM Shokat, ...
science 318 (5852), 944-949, 2007
The unfolded protein response signals through high-order assembly of Ire1
AV Korennykh, PF Egea, AA Korostelev, J Finer-Moore, C Zhang, ...
Nature 457 (7230), 687-693, 2009
Structural bioinformatics-based design of selective, irreversible kinase inhibitors
MS Cohen, C Zhang, KM Shokat, J Taunton
Science 308 (5726), 1318-1321, 2005
Single-cell landscape of immunological responses in patients with COVID-19
JY Zhang, XM Wang, X Xing, Z Xu, C Zhang, JW Song, X Fan, P Xia, ...
Nature immunology 21 (9), 1107-1118, 2020
The advantages of targeted protein degradation over inhibition: an RTK case study
GM Burslem, BE Smith, AC Lai, S Jaime-Figueroa, DC McQuaid, ...
Cell chemical biology 25 (1), 67-77. e3, 2018
Discovery of nitrate–CPK–NLP signalling in central nutrient–growth networks
K Liu, Y Niu, M Konishi, Y Wu, H Du, H Sun Chung, L Li, M Boudsocq, ...
Nature 545 (7654), 311-316, 2017
Chemical genetic analysis of the time course of signal transduction by JNK
JJ Ventura, A Hübner, C Zhang, RA Flavell, KM Shokat, RJ Davis
Molecular cell 21 (5), 701-710, 2006
Immunological and inflammatory profiles in mild and severe cases of COVID-19
JW Song, C Zhang, X Fan, FP Meng, Z Xu, P Xia, WJ Cao, T Yang, XP Dai, ...
Nature communications 11 (1), 3410, 2020
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
S Larochelle, R Amat, K Glover-Cutter, M Sansó, C Zhang, JJ Allen, ...
Nature structural & molecular biology 19 (11), 1108-1115, 2012
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II
K Glover-Cutter, S Larochelle, B Erickson, C Zhang, K Shokat, RP Fisher, ...
Molecular and cellular biology 29 (20), 5455-5464, 2009
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast
B Bodenmiller, S Wanka, C Kraft, J Urban, D Campbell, PG Pedrioli, ...
Science signaling 3 (153), rs4-rs4, 2010
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
S Lourido, J Shuman, C Zhang, KM Shokat, R Hui, LD Sibley
Nature 465 (7296), 359-362, 2010
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2
KR Benjamin, C Zhang, KM Shokat, I Herskowitz
Genes & development 17 (12), 1524-1539, 2003
Inhibitor hijacking of Akt activation
T Okuzumi, D Fiedler, C Zhang, DC Gray, B Aizenstein, R Hoffman, ...
Nature chemical biology 5 (7), 484-493, 2009
An unbiased cell morphology–based screen for new, biologically active small molecules
M Tanaka, R Bateman, D Rauh, E Vaisberg, S Ramachandani, C Zhang, ...
PLoS biology 3 (5), e128, 2005
Bypassing a kinase activity with an ATP-competitive drug
FR Papa, C Zhang, K Shokat, P Walter
Science 302 (5650), 1533-1537, 2003
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells
ME Burkard, CL Randall, S Larochelle, C Zhang, KM Shokat, RP Fisher, ...
Proceedings of the National Academy of Sciences 104 (11), 4383-4388, 2007
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
W Qi, K Zhao, J Gu, Y Huang, Y Wang, H Zhang, M Zhang, J Zhang, Z Yu, ...
Nature chemical biology 13 (4), 381-388, 2017
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
S Larochelle, KA Merrick, ME Terret, L Wohlbold, NM Barboza, C Zhang, ...
Molecular cell 25 (6), 839-850, 2007
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