Ewa Michalak
Ewa Michalak
Peter MacCallum Cancer Centre
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p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
A Villunger, EM Michalak, L Coultas, F Mullauer, G Bock, ...
Science 302 (5647), 1036-1038, 2003
ER stress triggers apoptosis by activating BH3-only protein Bim
H Puthalakath, LA O'Reilly, P Gunn, L Lee, PN Kelly, ND Huntington, ...
Cell 129 (7), 1337-1349, 2007
BH3-only proteins Puma and Bim are rate-limiting for γ-radiation–and glucocorticoid-induced apoptosis of lymphoid cells in vivo
M Erlacher, EM Michalak, PN Kelly, V Labi, H Niederegger, L Coultas, ...
Blood 106 (13), 4131-4138, 2005
The roles of DNA, RNA and histone methylation in ageing and cancer
EM Michalak, ML Burr, AJ Bannister, MA Dawson
Nature reviews Molecular cell biology 20 (10), 573-589, 2019
p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa
LJ Valente, DHD Gray, EM Michalak, J Pinon-Hofbauer, A Egle, CL Scott, ...
Cell reports 3 (5), 1339-1345, 2013
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer
ML Burr, CE Sparbier, KL Chan, YC Chan, A Kersbergen, EYN Lam, ...
Cancer cell 36 (4), 385-401. e8, 2019
Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
ND Huntington, H Puthalakath, P Gunn, E Naik, EM Michalak, MJ Smyth, ...
Nature immunology 8 (8), 856-863, 2007
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
M Erlacher, V Labi, C Manzl, G Böck, A Tzankov, G Häcker, E Michalak, ...
The Journal of experimental medicine 203 (13), 2939-2951, 2006
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
EM Michalak, A Villunger, JM Adams, A Strasser
Cell Death & Differentiation 15 (6), 1019-1029, 2008
DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa
JB Kerr, KJ Hutt, EM Michalak, M Cook, CJ Vandenberg, SH Liew, ...
Molecular cell 48 (3), 343-352, 2012
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
EF Lee, PE Czabotar, MF Van Delft, EM Michalak, MJ Boyle, SN Willis, ...
The Journal of cell biology 180 (2), 341-355, 2008
Developmental stage‐specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland
KE de Visser, M Ciampricotti, EM Michalak, DWM Tan, EN Speksnijder, ...
The Journal of pathology 228 (3), 300-309, 2012
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
EM Michalak, ES Jansen, L Happo, MS Cragg, L Tai, GK Smyth, ...
Cell Death & Differentiation 16 (5), 684-696, 2009
Death squads enlisted by the tumour suppressor p53
E Michalak, A Villunger, M Erlacher, A Strasser
Biochemical and biophysical research communications 331 (3), 786-798, 2005
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
E Naik, EM Michalak, A Villunger, JM Adams, A Strasser
The Journal of cell biology 176 (4), 415-424, 2007
Apoptosis-promoted tumorigenesis: γ-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death
EM Michalak, CJ Vandenberg, ARD Delbridge, L Wu, CL Scott, JM Adams, ...
Genes & development 24 (15), 1608-1613, 2010
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer
L Henneman, MH van Miltenburg, EM Michalak, TM Braumuller, ...
Proceedings of the National Academy of Sciences 112 (27), 8409-8414, 2015
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
L Happo, MS Cragg, B Phipson, JM Haga, ES Jansen, MJ Herold, ...
Blood, The Journal of the American Society of Hematology 116 (24), 5256-5267, 2010
Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells
IJ Huijbers, R Bin Ali, C Pritchard, M Cozijnsen, MC Kwon, N Proost, ...
EMBO molecular medicine 6 (2), 212-225, 2014
Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
PG Ekert, AM Jabbour, A Manoharan, JE Heraud, J Yu, M Pakusch, ...
Blood 108 (5), 1461-1468, 2006
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