| Interaction of Poly(butylcyanoacrylate) Nanoparticles with the Blood-Brain Barrier in vivo and in vitro RN Alyaudtin, A Reichel, R Löbenberg, P Ramge, J Kreuter, DJ Begley Journal of drug targeting 9 (3), 209-221, 2001 | 255 | 2001 |
| Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept A Reichel Chemistry & biodiversity 6 (11), 2030-2049, 2009 | 192 | 2009 |
| An overview of in vitro techniques for blood-brain barrier studies A Reichel, DJ Begley, NJ Abbott The Blood-Brain Barrier: Biology and Research Protocols, 307-324, 2003 | 177 | 2003 |
| The role of blood-brain barrier studies in the pharmaceutical industry A Reichel Current drug metabolism 7 (2), 183-203, 2006 | 175 | 2006 |
| The Lab Oddity Prevails: Discovery of Pan‐CDK Inhibitor (R)‐S‐Cyclopropyl‐S‐(4‐{[4‐{[(1R,2R)‐2‐hydroxy‐1‐methylpropyl]oxy}‐5‐(trifluoromethyl)pyrimidin‐2 … U Lücking, R Jautelat, M Krüger, T Brumby, P Lienau, M Schäfer, H Briem, ... ChemMedChem 8 (7), 1067-1085, 2013 | 173 | 2013 |
| Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female … C MacLean, U Moenning, A Reichel, G Fricker Drug Metabolism and Disposition 36 (7), 1249-1254, 2008 | 173 | 2008 |
| Mechanism-based inhibition: deriving KI and kinact directly from time-dependent IC50 values BF Krippendorff, R Neuhaus, P Lienau, A Reichel, W Huisinga SLAS Discovery 14 (8), 913-923, 2009 | 165 | 2009 |
| Drug resistance in epilepsy: the role of the blood–brain barrier NJ Abbott, EU Khan, CMS Rollinson, A Reichel, D Janigro, ... Mechanisms of Drug Resistance in Epilepsy: Novartis Foundation Symposium 243 …, 2002 | 164 | 2002 |
| Potential of immobilized artificial membranes for predicting drug penetration across the blood− brain barrier A Reichel, DJ Begley Pharmaceutical research 15, 1270-1274, 1998 | 164 | 1998 |
| Straightforward strategies for the preparation of NH-sulfoximines: a serendipitous story JA Bull, L Degennaro, R Luisi Synlett 28 (19), 2525-2538, 2017 | 131 | 2017 |
| Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines M Chishty, A Reichel, J Siva, NJ Abbott, DJ Begley Journal of drug targeting 9 (3), 223-228, 2001 | 110 | 2001 |
| Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats D Mitschke, A Reichel, G Fricker, U Moenning Drug Metabolism and Disposition 36 (6), 1039-1045, 2008 | 96 | 2008 |
| Pharmacokinetics in drug discovery: an exposure-centred approach to optimising and predicting drug efficacy and safety A Reichel, P Lienau New approaches to drug discovery, 235-260, 2016 | 86 | 2016 |
| Optimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery BF Krippendorff, P Lienau, A Reichel, W Huisinga Journal of Biomolecular Screening 12 (1), 92-99, 2007 | 77 | 2007 |
| Piperidine renin inhibitors: from leads to drug candidates HP Märki, A Binggeli, B Bittner, V Bohner-Lang, V Breu, D Bur, ... Il Farmaco 56 (1-2), 21-27, 2001 | 71 | 2001 |
| Development and application of physiologically based pharmacokinetic‐modeling tools to support drug discovery C Lüpfert, A Reichel Chemistry & biodiversity 2 (11), 1462-1486, 2005 | 67 | 2005 |
| Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development I Loryan, A Reichel, B Feng, C Bundgaard, C Shaffer, C Kalvass, ... Pharmaceutical research 39 (7), 1321-1341, 2022 | 55 | 2022 |
| N-glycosylation of ABC transporters is associated with functional activity in sandwich-cultured rat hepatocytes V Draheim, A Reichel, W Weitschies, U Moenning European journal of pharmaceutical sciences 41 (2), 201-209, 2010 | 47 | 2010 |
| Piperazine derivatives that destabilize androgen receptors A Cleve, C Huwe, V Schulze, H Morack, D Zopf, J Hoffmann, A Reichel US Patent 6,861,432, 2005 | 47 | 2005 |
| A probabilistic approach to classifying metabolic stability A Schwaighofer, T Schroeter, S Mika, K Hansen, A Ter Laak, P Lienau, ... Journal of chemical information and modeling 48 (4), 785-796, 2008 | 46 | 2008 |
